Epithelioid hemangioma (angiolymphoid hyperplasia with eosinophilia) in the oral mucosa.
Epithelioid hemangioma (angiolymphoid hyperplasia with eosinophilia) in the oral mucosa.
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DOI：
10.4103/0970-9290.100439
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发表时间：
2012-03-01
期刊：
影响因子：
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通讯作者：
Keluskar, Vaishali
中科院分区：
文献类型：
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作者：
Aggarwal, Anshul;Keluskar, Vaishali
血管淋巴样增生伴嗜酸性粒细胞增多症（ALHE）是一种罕见的良性疾病，其病因和发病机制仍有争议。临床上，它的特点是皮肤丘疹或结节的头部和颈部。文献显示口腔粘膜中的这种实体的病例非常少。在此，我们报告一例25岁女性的ALHE，她在下唇左嘴角处出现一个无痛的、5 mm x 5 mm的粘膜下结节。唇活检标本的组织学检查显示小血管增加。血管壁由突出的内皮细胞组成，具有组织细胞样外观，突出到管腔中。在血管周围还观察到许多嗜酸性粒细胞和淋巴细胞。根据以上结果作出ALHE的诊断。
Angiolymphoid hyperplasia with an eosinophilia (ALHE) is a rare benign entity whose etiology and pathogenesis is under debate. Clinically, it is characterised by cutaneous papules or nodules on the head and neck. Literature reveals very few cases of this entity in the oral mucosa. Here, we report a case of ALHE in a 25 year-old woman, who presented with a painless, 5mm x 5mm, sub mucosal erythematous nodule on left angle of mouth at lower lip. Histological examination of lip biopsy specimens revealed an increase in small vessels. The vascular walls consist of prominent endothelial cells with a histiocytoid appearance, which protruded into the lumen. Many eosinophils and lymphocytes were also seen around the vessels. The diagnosis of ALHE was made from the above findings.