A 1H and 13C nmr study of the radiation-induced degradation products of 2′-deoxythymidine derivatives: N-(2′-deoxy-β-D-erythropentofuranosyl) formamide
A 1H and 13C nmr study of the radiation-induced degradation products of 2′-deoxythymidine derivatives: N-(2′-deoxy-β-D-erythropentofuranosyl) formamide
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2-脱氧胸苷衍生物辐射诱导降解产物的 1H 和 13C nmr 研究：N-(2-脱氧-β-D-赤戊呋喃糖基)甲酰胺
DOI：
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发表时间：
1981
期刊：
影响因子：
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通讯作者：
F. Hruska
中科院分区：
文献类型：
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作者：
J. Cadet;R. Nardin;L. Voituriez;M. Remin;F. Hruska
N-(2'-Deoxy-β-D-erythropentofuranosyl) formamide 是一种电离辐射诱导的 2'-deoxythymidine 降解产物。这项工作描述了该分子的简单化学合成，并讨论了 1H 和 13C nmr 研究的结果。计算了关于酰胺键的顺反异构化的旋转势垒，并给出了水溶液中顺式和反式异构体的分子构象的详细信息。
N-(2′-Deoxy-β-D-erythropentofuranosyl) formamide is an ionizing radiation-induced degradation product of 2′-deoxythymidine. This work describes a facile chemical synthesis of this molecule, and discusses the results of an 1H and 13C nmr study. The rotational barrier to cis–trans isomerization about the amide linkage is calculated, and details of the molecular conformation of the cis and trans isomers in aqueous solution are presented.