T cells and autoantibodies to human HSP70 in Type I diabetes in children
T cells and autoantibodies to human HSP70 in Type I diabetes in children
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DOI：
10.1016/s0896-8411(03)00038-6
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发表时间：
2003-06-01
影响因子：
12.8
通讯作者：
Cohen, IR
中科院分区：
文献类型：
--
作者：
Abulafia-Lapid, R;Gillis, D;Cohen, IR
我们研究了25名新诊断为I型糖尿病的儿童（平均年龄10.1 ± 3.8岁）的T细胞增殖反应（刺激指数：SI）和对人HSP 60、HSP 70和HSP 90蛋白的自身抗体。对照组T.细胞包括25名成人和3名儿童供体，无1型糖尿病。抗体对照包括10名儿科受试者。试验组T细胞对HSP 70的反应（平均SI = 4.5 ± 3.1）显著高于对照组（平均SI = 1.4 ± 0.6; p
We studied T-cell proliferative responses (stimulation index: SI) and autoantibodies to human HSP60, HSP70 and HSP90 proteins in 25 children (mean age 10.1 +/- 3.8 years) newly diagnosed with Type I diabetes. The control group for T. cells included 25 adults and three pediatric donors without Type 1 diabetes. Controls for antibodies included 10 pediatric subjects. The T-cell responses to HSP70 of the test group (mean SI = 4.5 +/- 3.1) were significantly greater than those of the control group (mean SI = 1.4 0.6; p