Transition of Neural Activity From the Chaotic Bipolar-Disorder State to the Periodic Healthy State Using External Feedback Signals
Transition of Neural Activity From the Chaotic Bipolar-Disorder State to the Periodic Healthy State Using External Feedback Signals
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DOI：
10.3389/fncom.2020.00076
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发表时间：
2020-08-28
影响因子：
3.2
通讯作者：
Takahashi, Tetsuya
中科院分区：
文献类型：
--
作者：
Doho, Hirotaka;Nobukawa, Sou;Takahashi, Tetsuya
时间疗法是一种治疗情绪障碍的方法，包括重度抑郁症、躁狂症和双相情感障碍（BD）。与情绪障碍的病理学相关的神经递质表现出昼夜节律。与情绪障碍相关的神经回路中的功能缺陷扰乱了昼夜节律;时间疗法是一种干预措施，有助于使患者的生物钟与周期性的日常周期同步，从而改善症状。Hadaeghi等人在以前的报告中提出了一个由额叶和感觉皮层神经网络以及下丘脑组成的非线性动力学模型，以解释额叶皮层神经功能缺陷与BD患者昼夜节律/情绪转换紊乱之间的关系（以下简称Hadaeghi模型）。在这个模型中，额叶和感觉叶的神经活动在健康状态下表现出周期性行为;而在BD中，这种神经活动处于混沌-混沌不稳定状态;这种与健康周期性状态的时间偏离扰乱了下丘脑的昼夜节律起搏器。在这项研究中，我们提出了一种干预的基础上的反馈方法，称为“减少区域的轨道”（RRO）的方法，以促进过渡的干扰额皮质神经活动的基础BD健康的周期性活动。我们的模拟是基于Hadaeghi模型。我们使用的RRO反馈信号的基础上的返回地图结构的模拟额叶和感觉叶诱导同步与一个相对较弱的周期性信号对应的健康状况，通过施加适当的强度反馈。RRO反馈信号引起混沌共振，这有助于过渡到健康的，周期性的额叶神经活动，虽然这种同步被限制到一个相对较低的频率的周期性输入信号。此外，与单独施加的周期性信号相比，施加适当强度的RRO反馈信号降低了引起同步状态所需的周期性输入信号的幅度。总之，通过由RRO反馈方法引起的混沌共振效应，BD的受干扰的额叶神经活动特征的状态通过相对较弱的周期性扰动被转化为接近健康的周期性活动的状态。因此，RRO反馈调制时间疗法可能是一种创新的新型微创时间疗法。
Chronotherapy is a treatment for mood disorders, including major depressive disorder, mania, and bipolar disorder (BD). Neurotransmitters associated with the pathology of mood disorders exhibit circadian rhythms. A functional deficit in the neural circuits related to mood disorders disturbs the circadian rhythm; chronotherapy is an intervention that helps resynchronize the patient's biological clock with the periodic daily cycle, leading to amelioration of symptoms. In previous reports, Hadaeghi et al. proposed a non-linear dynamic model composed of the frontal and sensory cortical neural networks and the hypothalamus to explain the relationship between deficits in neural function in the frontal cortex and the disturbed circadian rhythm/mood transitions in BD (hereinafter referred to as the Hadaeghi model). In this model, neural activity in the frontal and sensory lobes exhibits periodic behavior in the healthy state; while in BD, this neural activity is in a state of chaos-chaos intermittency; this temporal departure from the healthy periodic state disturbs the circadian pacemaker in the hypothalamus. In this study, we propose an intervention based on a feedback method called the "reduced region of orbit" (RRO) method to facilitate the transition of the disturbed frontal cortical neural activity underlying BD to healthy periodic activity. Our simulation was based on the Hadaeghi model. We used an RRO feedback signal based on the return-map structure of the simulated frontal and sensory lobes to induce synchronization with a relatively weak periodic signal corresponding to the healthy condition by applying feedback of appropriate strength. The RRO feedback signal induces chaotic resonance, which facilitates the transition to healthy, periodic frontal neural activity, although this synchronization is restricted to a relatively low frequency of the periodic input signal. Additionally, applying an appropriate strength of the RRO feedback signal lowered the amplitude of the periodic input signal required to induce a synchronous state compared with the periodic signal applied alone. In conclusion, through a chaotic-resonance effect induced by the RRO feedback method, the state of the disturbed frontal neural activity characteristic of BD was transformed into a state close to healthy periodic activity by relatively weak periodic perturbations. Thus, RRO feedback-modulated chronotherapy might be an innovative new type of minimally invasive chronotherapy.