Effect of a glutamine-enriched enteral diet on intestinal permeability and infectious morbidity at 28 days in critically ill patients with systemic inflammatory response syndrome:: A randomized, single-blind, prospective, multicenter study
Effect of a glutamine-enriched enteral diet on intestinal permeability and infectious morbidity at 28 days in critically ill patients with systemic inflammatory response syndrome:: A randomized, single-blind, prospective, multicenter study
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DOI：
10.1016/s0899-9007(02)00847-x
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发表时间：
2002-09-01
期刊：
影响因子：
4.4
通讯作者：
Acosta, JA
中科院分区：
文献类型：
--
作者：
Conejero, R;Bonet, A;Acosta, JA
目的：我们研究了富含谷氨酰胺的肠内饮食对急性事件后出现全身性炎症反应综合征的危重患者肠通透性和感染性发病率和死亡率的影响。方法：11家三级医院重症监护病房参与了一项前瞻性、随机、单盲、多中心试验。84例任何病因的全身性炎症反应综合征患者被随机分配接受富含谷氨酰胺的肠内饮食或不含谷氨酰胺的对照饮食。结果：大多数患者接受了计划的热量摄入。谷氨酰胺组感染人数少于对照组（11例vs 17例，P < 0.05），相对危险度为0.5（95%可信区间= 0.3-0.9）。最常见的感染是院内肺炎，对照组11例（33%），谷氨酰胺组6例（14%）。在其他感染方面没有差异。死亡率或停留时间。乳果糖-甘露醇试验评估的肠道通透性在两组中没有变化。结论：富谷氨酰胺肠内饮食可降低全身性炎症反应综合征患者的院内感染。(C) Elsevier Science Inc., 2002。
OBJECTIVES: We investigated the effect of a glutamine-enriched enteral diet on intestinal permeability and infectious morbidity and mortality in critically ill patients who developed systemic inflammatory response syndrome after an acute event.METHODS: Eleven intensive care units in tertiary-care hospitals participated in a prospective, randomized, single blind, multicenter trial. Eighty-four patients with systemic inflammatory response syndrome of any etiology were randomly allocated to receive a glutamine-enriched enteral diet or a control diet without glutamine.RESULTS: Most patients received the planned caloric intake. The number of infected patients was smaller in the glutamine group than in the control group (11 versus 17 patients, P < 0.05), with a relative risk of 0.5 (95% confidence interval = 0.3-0.9). The most frequent infection was nosocomial pneumonia, with 11 (33%) patients in the control group and 6 (14%) in the glutamine group. There were no differences with respect to, other infections., mortality, or length of stay. Intestinal permeability as assessed by the lactulose-mannitol test was unchanged in both groups.CONCLUSION: Glutamine-enriched enteral diets can decrease nosocomial infections in patients with systemic inflammatory response syndrome. (C) Elsevier Science Inc. 2002.