DOXORUBICIN PHARMACOKINETICS AFTER INTRAVENOUS AND INTRAPERITONEAL ADMINISTRATION IN THE NUDE-MOUSE
DOXORUBICIN PHARMACOKINETICS AFTER INTRAVENOUS AND INTRAPERITONEAL ADMINISTRATION IN THE NUDE-MOUSE
复制标题
DOI：
10.1007/bf00434396
复制
发表时间：
1981-01-01
影响因子：
3
通讯作者：
JOHANSEN, PB
中科院分区：
文献类型：
--
作者：
JOHANSEN, PB
研究了单次静脉和腹腔给药12mg /kg的阿霉素在裸鼠体内的药代动力学。腹腔给药后，肾脏、心脏和横纹肌中阿霉素浓度曲线下的面积约为静脉注射后的一半，而血浆和肝脏在2小时的分布期后显示出几乎相同的浓度。裸鼠和正常小鼠在药代动力学上仅发现微小差异。
The pharmacokinetics of doxorubicin in nude mice have been investigated following intravenous and intraperitoneal administration of single doses of 12 mg/kg. The areas under the concentration curves of doxorubicin in kidney, heart, and striated muscle following intraperitoneal administration were approximately half the areas following intravenous injection, whereas plasma and liver showed nearly identical concentrations after a distribution phase of 2 h. Only minor differences in pharmacokinetics were found between nude and normal mice.