Choline metabolism-based molecular diagnosis of cancer: an update.
Choline metabolism-based molecular diagnosis of cancer: an update.
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DOI：
10.1586/14737159.2015.1039515
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发表时间：
2015-06
影响因子：
5.1
通讯作者：
Bhujwalla ZM
中科院分区：
文献类型：
--
作者：
Glunde K;Penet MF;Jiang L;Jacobs MA;Bhujwalla ZM
胆碱代谢异常在多种癌症中继续被发现。胆碱代谢异常的分子原因是胆碱激酶-α、乙醇胺激酶-α、磷脂酰胆碱特异性磷脂酶C和-D和甘油磷酸胆碱磷酸二酯酶以及几种胆碱转运蛋白的变化。这些酶变化的最终结果是磷酸胆碱和总胆碱（tCho）增加，在某些癌症中，甘油磷酸胆碱相对减少。通过1H磁共振光谱检测到的tCho信号增加正在被评估为多种癌症的诊断标志物。胆碱转运蛋白和胆碱激酶-α的表达和活性增加，促进了放射性标记胆碱类似物作为PET成像示踪剂的发展。正在研究tCho 1H磁共振波谱和胆碱PET，以检测对治疗的反应。介导胆碱代谢异常的酶正被探索作为癌症治疗的靶点。本文综述了近年来胆碱代谢在肿瘤中的分子、治疗和临床研究进展。
Abnormal choline metabolism continues to be identified in multiple cancers. Molecular causes of abnormal choline metabolism are changes in choline kinase-α, ethanolamine kinase-α, phosphatidylcholine-specific phospholipase C and -D and glycerophosphocholine phosphodiesterases, as well as several choline transporters. The net outcome of these enzymatic changes is an increase in phosphocholine and total choline (tCho) and, in some cancers, a relative decrease of glycerophosphocholine. The increased tCho signal detected by 1H magnetic resonance spectroscopy is being evaluated as a diagnostic marker in multiple cancers. Increased expression and activity of choline transporters and choline kinase-α have spurred the development of radiolabeled choline analogs as PET imaging tracers. Both tCho 1H magnetic resonance spectroscopy and choline PET are being investigated to detect response to treatment. Enzymes mediating the abnormal choline metabolism are being explored as targets for cancer therapy. This review highlights recent molecular, therapeutic and clinical advances in choline metabolism in cancer.