Quantitative analysis of the microvascular architecture observed on magnification endoscopy in cancerous and benign gastric lesions
Quantitative analysis of the microvascular architecture observed on magnification endoscopy in cancerous and benign gastric lesions
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DOI：
10.1055/s-2005-870339
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发表时间：
2005-12-01
期刊：
影响因子：
9.3
通讯作者：
Goto, H
中科院分区：
文献类型：
--
作者：
Ohashi, A;Niwa, Y;Goto, H
背景和研究目的：胃癌仍然是日本常见的恶性肿瘤。本研究的目的是尝试使用图像分析对放大内镜观察到的微血管结构进行定量评价，并调查该方法是否能够区分胃癌和良性病变。共132例患者进行了研究，使用放大内镜，并在71例患者进行了图像分析（早期胃癌32例，良性病变39例）。由于图像质量不够好，无法对其他61例患者进行分析。从胃粘膜的放大图像中选择感兴趣的正方形区域。从这一点上，我们提取的血管图像对应的微血管和计算的平均口径的血管中的区域interest.Results：图像分析提供了良好的质量图像的微血管和微血管结构的评价。17例分化型腺癌的平均血管管径为4.454pixel，15例未分化型腺癌为4.319pixel，39例良性病变为4.034pixel。胃癌与良性病变之间有显著性差异（P < 0.0001）。手术切除的肿瘤的组织学调查表明，在癌性病变的微血管的平均口径大于周围mucosa.Conclusions微血管的微血管构筑的图像分析是有用的评价胃粘膜，和计算的平均口径的血管可能被证明有助于胃癌的鉴别诊断。然而，由于图像质量不足，132例患者中有61例无法进行分析，这代表了该诊断方法的显著局限性。
Background and Study Aims: Gastric cancer remains a common malignant tumor in Japan. The aim of this study was to attempt a quantitative evaluation of the microvascular architecture observed by magnification endoscopy using image analysis, and to investigate whether this method is able to distinguish between gastric cancers and benign lesions.Patients and Methods: A total of 132 patients were studied using magnification endoscopy, and image analysis was performed in 71 patients (32 patients with early gastric cancer, 39 patients with benign lesions). Analysis was not possible in the other 61 patients because the quality of the image was not good enough. A square region of interest was selected from the magnified images of the gastric mucosa. From this we extracted the vascular images corresponding to microvessels and calculated the mean caliber of vessels in the region of interest.Results: Image analysis provided good-quality images of micro-vessels and enabled evaluation of the microvascular architecture. The mean caliber of vessels was 4.454 pixels in 17 differentiated adenocarcinomas, 4.319 pixels in 15 undifferentiated adenocarcinomas, and 4.034 pixels in the 39 benign lesions. This represented a significant difference between gastric cancers and benign lesions (P < 0.0001). Histopathological investigation of surgically resected tumors demonstrated the mean caliber of microvessels in cancerous lesions to be greater than that of microvessels in the surrounding mucosa.Conclusions: Image analysis was useful for evaluating the microvascular architecture of the gastric mucosa, and calculation of the mean caliber of the vessels may prove helpful in the differential diagnosis of gastric cancers. However, analysis was not possible in 61 of the 132 patients studied because of inadequate image quality, and this represents a significant limitation of this diagnostic method.