Impaired Retinal Circulation in Patients with Type 2 Diabetes Mellitus: Retinal Laser Doppler Velocimetry Study
Impaired Retinal Circulation in Patients with Type 2 Diabetes Mellitus: Retinal Laser Doppler Velocimetry Study
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DOI：
10.1167/iovs.10-5364
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发表时间：
2010-12-01
影响因子：
4.4
通讯作者：
Yoshida, Akitoshi
中科院分区：
文献类型：
--
作者：
Nagaoka, Taiji;Sato, Eiichi;Yoshida, Akitoshi
目的.评价2型糖尿病无视网膜病变或早期糖尿病视网膜病变患者与对照眼视网膜循环的差异。对75只非糖尿病眼和194只2型糖尿病眼进行了评价。将2型糖尿病眼分为两组：无糖尿病视网膜病变（NDR）的139只眼（139例患者）和轻度非增殖性糖尿病视网膜病变（NPDR）的55只眼（55例患者）。采用激光多普勒测速仪测量视网膜循环参数，并确定影响2型糖尿病患者视网膜血流动力学的因素。NDR组和轻度NPDR组的平均血流速度（V）和视网膜血流（RBF）均显著低于非DM组（P < 0.01）。糖尿病视网膜病变组的直径和室壁剪切率也显著低于非糖尿病对照眼（P < 0.05）。多元回归分析显示，RBF与血清低密度脂蛋白、肌酐呈独立负相关。HbA 1c在最低RBF四分位数的参与者中显著高于最高四分位数的参与者（P <0. 05）。结果表明，RBF可能会降低2型糖尿病患者无视网膜病变和轻度视网膜病变。（Invest Ophthalmol维斯科学。2010;51：6729-6734）DOI：10.1167/iovs.10-5364
PURPOSE. To evaluate the differences in retinal circulation in eyes of patients with type 2 diabetes with no or early-stage diabetic retinopathy compared with control eyes.METHODS. Seventy-five nondiabetic eyes and 194 eyes with type 2 diabetes mellitus were evaluated. The type 2 diabetic eyes were classified into two groups: 139 eyes (139 patients) without diabetic retinopathy (NDR) and 55 eyes (55 patients) with mild nonproliferative diabetic retinopathy (NPDR). The retinal circulatory parameters were measured with laser Doppler velocimetry, and the factors that affect retinal hemodynamics were determined in a cross-sectional population of patients with type 2 diabetes.RESULTS. The group-averaged blood velocity (V) and retinal blood flow (RBF) in the NDR and mild NPDR groups were significantly (P < 0.01) lower than in the non-DM group. The diameter and wall shear rate were also significantly (P < 0.05) lower in the NDR group than in the nondiabetic control eyes. Multiple regression analysis showed that the RBF was independently and negatively correlated with serum low-density lipoprotein and creatinine. HbA1c was significantly (P < 0.05) higher in participants in the lowest RBF quartile than in the highest quartiles.CONCLUSIONS. The results indicate that the RBF may decrease in patients with type 2 diabetes without retinopathy and in those with mild retinopathy. (Invest Ophthalmol Vis Sci. 2010;51:6729-6734) DOI:10.1167/iovs.10-5364