Higher bioelectric potentials due to decreased chloride absorption in the sweat glands of patients with cystic fibrosis.
Higher bioelectric potentials due to decreased chloride absorption in the sweat glands of patients with cystic fibrosis.
复制标题
由于囊性纤维化患者汗腺吸收氯离子减少，生物电势较高。
DOI：
10.1056/nejm198305193082002
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Bijman,J
中科院分区：
文献类型：
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作者：
Quinton,PM;Bijman,J
囊性纤维化患者的汗液、唾液和胰腺分泌物的电解质成分存在特征性紊乱。我们研究了八名囊性纤维化患者和七名正常志愿者的汗腺电特性，以确定在这种疾病中钠吸收抑制的基础。患者47个汗腺的平均电位为-66.3±2.1 mV，而正常对照组39个汗腺的平均电位为-29.8±3.2 mV（P<0.001）。 6 名患者的 33 个腺体的平均汗液分泌率与 6 名对照者的 34 个腺体的平均汗液分泌率没有显着差异，但患者汗滴中钠、氯和钾的平均浓度显着较高。计算得出的患者汗腺钠和氯重吸收率均低于正常对照，但氯重吸收比钠重吸收降低更显着。我们的结论是，上皮对氯的通透性降低可以解释囊性纤维化中汗液电解质的特征性变化，并且可能是该疾病的普遍异常。 （新英格兰医学杂志 1983；308：1185–9。）
Patients with cystic fibrosis have characteristic disturbances in the electrolyte composition of their sweat, saliva, and pancreatic secretions. We studied the electrical properties of sweat glands in eight patients with cystic fibrosis and in seven normal volunteers to determine the basis of the well-documented inhibition of sodium absorption in this disease. The average electrical potential across 47 sweat glands in the patients was -66.3±2.1 mV, as compared with -29.8±3.2 mV for 39 glands in the normal controls (P<0.001). The average sweat-secretion rate in 33 glands from six patients was not significantly different from that in 34 glands from six controls, but average concentrations of sodium, chloride, and potassium were significantly higher in sweat droplets from the patients. Calculated rates of both sodium and chloride reabsorption were lower in sweat glands of patients than of normal controls, but chloride reabsorption was more markedly reduced than sodium reabsorption. We conclude that a decrease in epithelial permeability to chloride may explain the characteristic changes in sweat electrolytes in cystic fibrosis and could be a generalized abnormality in the disease. (N Engl J Med 1983; 308:1185–9.)