Cortex-wide response mode of VIP-expressing inhibitory neurons by reward and punishment.
Cortex-wide response mode of VIP-expressing inhibitory neurons by reward and punishment.
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DOI：
10.7554/elife.78815
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发表时间：
2022-11-23
期刊：
影响因子：
7.7
通讯作者：
Rózsa B
中科院分区：
文献类型：
--
作者：
Szadai Z;Pi HJ;Chevy Q;Ócsai K;Albeanu DF;Chiovini B;Szalay G;Katona G;Kepecs A;Rózsa B
新皮层通常被划分为不同的区域，每个区域都有不同的功能，但都可以从强化反馈中受益，以通知和更新局部处理。然而，像奖励和惩罚这样的全局信号如何在局部皮层计算中表现出来，这仍然是一个谜。以前，我们确定了皮质神经元类型，血管活性肠多肽（VIP）表达的中间神经元，在听觉皮层，招募的行为抑制剂和介导的去抑制控制抑制其他抑制性神经元。由于同样的去抑制皮层回路几乎存在于整个皮层，我们想知道VIP神经元是否同样被整个皮层的神经元招募。我们使用三维随机访问双光子显微镜和纤维光度法在几十个皮层区域监测VIP神经活动，而小鼠学习听觉辨别任务。我们发现，奖励和惩罚在初始学习过程中产生快速，皮层范围内的激活大多数VIP中间神经元。这种全局招募模式显示了个体神经元和跨区域的时间动态变化。无论是在视觉皮层VIP中间神经元的弱感觉调谐，也不是他们的唤醒状态调制是完全预测的唤醒反应。我们认为，皮层VIP中间神经元的全球响应模式支持细胞类型特定的电路机制，生物体水平的信息调节局部电路处理和可塑性。
Neocortex is classically divided into distinct areas, each specializing in different function, but all could benefit from reinforcement feedback to inform and update local processing. Yet it remains elusive how global signals like reward and punishment are represented in local cortical computations. Previously, we identified a cortical neuron type, vasoactive intestinal polypeptide (VIP)-expressing interneurons, in auditory cortex that is recruited by behavioral reinforcers and mediates disinhibitory control by inhibiting other inhibitory neurons. As the same disinhibitory cortical circuit is present virtually throughout cortex, we wondered whether VIP neurons are likewise recruited by reinforcers throughout cortex. We monitored VIP neural activity in dozens of cortical regions using three-dimensional random access two-photon microscopy and fiber photometry while mice learned an auditory discrimination task. We found that reward and punishment during initial learning produce rapid, cortex-wide activation of most VIP interneurons. This global recruitment mode showed variations in temporal dynamics in individual neurons and across areas. Neither the weak sensory tuning of VIP interneurons in visual cortex nor their arousal state modulation was fully predictive of reinforcer responses. We suggest that the global response mode of cortical VIP interneurons supports a cell-type-specific circuit mechanism by which organism-level information about reinforcers regulates local circuit processing and plasticity.
影响因子：
3.7
作者：
Pankhurst MW;Gell DA;Butler CW;Kirkcaldie MT;West AK;Chung RS
通讯作者：
Chung RS