Enhancer point mutation results in a homeotic transformation in Drosophila.
Enhancer point mutation results in a homeotic transformation in Drosophila.
复制标题
增强子点突变导致果蝇同源异型转化。
DOI：
10.1126/science.7909957
复制
发表时间：
1994
期刊：
影响因子：
56.9
通讯作者：
M. O’Connor
中科院分区：
文献类型：
--
作者：
M. Shimell;J. Simon;W. Bender;M. O’Connor
In Drosophila, the misexpression or altered activity of genes from the bithorax complex results in homeotic transformations. One of these genes, abd-A, normally specifies the identity of the second through fourth abdominal segments (A2 to A4). In the dominant Hyperabdominal mutations (Hab), portions of the third thoracic segment (T3) are transformed toward A2 as the result of ectopic abd-A expression. Sequence analysis and deoxyribonuclease I footprinting demonstrate that the misexpression of abd-A in two independent Hab mutations results from the same single base change in a binding site for the gap gene Krüppel protein. These results establish that the spatial limits of the homeotic genes are directly regulated by gap gene products.
影响因子：
--
作者：
T. Kaufman;Mark A. Seeger;G. Olsen
通讯作者：
T. Kaufman;Mark A. Seeger;G. Olsen
影响因子：
10.5
作者：
JIANG, J;KOSMAN, D;LEVINE, M
通讯作者：
LEVINE, M
果蝇同源异型基因 proboscipedia 在触角足 P1 控制下的异位表达导致显性胸部缺陷。
影响因子：
3.3
作者：
Cribbs,DL;Pattatucci,AM;Pultz,MA;Kaufman,TC
通讯作者：
Kaufman,TC