Abandonment of Treatment for Latent Tuberculosis Infection and Socioeconomic Factors in Children and Adolescents: Rio De Janeiro, Brazil.
Abandonment of Treatment for Latent Tuberculosis Infection and Socioeconomic Factors in Children and Adolescents: Rio De Janeiro, Brazil.
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DOI：
10.1371/journal.pone.0154843
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Sant'Anna CC
中科院分区：
文献类型：
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作者：
Mendonça AM;Kritski AL;Land MG;Sant'Anna CC
在结核病 (TB) 高负担国家，关于儿童和青少年使用异烟肼预防性治疗 (IPT) 的常规数据很少。描述接受常规护理的潜伏性结核感染 (LTBI) 儿童和青少年放弃 IPT 的相关因素。对巴西里约热内卢州一家儿科医院 286 例具有 IPT 指征的 LTBI 病例进行回顾性（2005-2009 年）描述性研究。对六个月内放弃 IPT 的风险进行了生存分析，包括使用 Cox 比例风险模型的多变量分析。在 245 例 LTBI 病例中，62 例放弃了 IPT（25.3%；95% CI：20%-31%）。在多变量分析中，与IPT遗弃风险比相关的变量是居住地的人类发展指数（HDI）（风险比—HR：0.004；0.000-0.569）以及与未接受抗结核治疗的成年人的接触（HR：7.30；1.00-53.3）。这项研究揭示了放弃 IPT 与居住地的社会经济条件和积极结核病治疗依从性差之间的相关性。促进对儿童接触者的预防性治疗和指示病例的治疗性治疗的教育措施应针对整个家庭环境。
Routine data on the use of isoniazid preventive therapy (IPT) in children and adolescents are scarce in high tuberculosis (TB) burden countries. To describe the factors related to abandonment of IPT in children and adolescents with latent tuberculosis infection (LTBI) receiving routine care. Retrospective (2005–2009) descriptive study of 286 LTBI cases with indication of IPT and serviced at a pediatric hospital in the State of Rio de Janeiro, Brazil. Survival analysis of the risk of abandonment of IPT over six months was performed, including multivariate analysis using the Cox proportional hazards model. Out of the 245 cases of LTBI included, 62 abandoned IPT (25.3%; 95% CI: 20%-31%). On multivariate analysis, the variables related to the IPT abandonment hazard ratio were the Human Development Index (HDI) (hazard ratio—HR: 0.004; 0.000–0.569) of the place of residence and the contact with adults that were not undergoing anti-TB treatment (HR: 7.30; 1.00–53.3). This study reveals the relevance of the relation of abandonment of IPT to the socioeconomic conditions at the place of residence and poor adherence to the active TB treatment. Educational measures to stimulate preventive treatment of child contacts and curative treatment of index cases should target the full familial setting.
DOI：
10.1590/s0103-05822014000100001
发表时间：
2014-03
期刊：
Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo
影响因子：
--
作者：
Succi RC
通讯作者：
Succi RC