Gross morphological brain changes with chronic, heavy cannabis use
Gross morphological brain changes with chronic, heavy cannabis use
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DOI：
10.1192/bjp.bp.114.151407
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发表时间：
2015-01-01
影响因子：
10.5
通讯作者：
Yuecel, Murat
中科院分区：
文献类型：
--
作者：
Lorenzetti, Valentina;Solowij, Nadia;Yuecel, Murat
We investigated the morphology of multiple brain regions in a rare sample of 15 very heavy cannabis users with minimal psychiatric comorbidity or significant exposure to other substances (compared with 15 age- and IQ-matched non-cannabis-using controls) using manual techniques. Heavy cannabis users demonstrated smaller hippocampus and amygdala volumes, but no alterations of the orbitofrontal and anterior- and paracingulate cortices, or the pituitary gland. These findings indicate that chronic cannabis use has a selective and detrimental impact on the morphology of the mediotemporal lobe.
