The astroglial protein S100B and visually evoked event-related potentials before and after antidepressant treatment
The astroglial protein S100B and visually evoked event-related potentials before and after antidepressant treatment
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DOI：
10.1007/s00213-004-1999-z
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发表时间：
2005-03-01
影响因子：
3.4
通讯作者：
Rothermundt, M
中科院分区：
文献类型：
--
作者：
Hetzel, G;Moeller, O;Rothermundt, M
原理：S100B是一种星形细胞钙结合蛋白，在纳摩尔浓度下对神经元和神经胶质细胞具有神经保护和再生作用。增加的水平已被证明与重度抑郁症的治疗反应呈正相关。据报道，抑郁症患者的事件相关电位（ERP）受损。目的：研究抑郁症患者S100B与视觉诱发ERP的关系。方法：对18例重度抑郁症患者进行抗抑郁治疗前后4周的血清ERP和S100B浓度测定。结果：与健康对照组相比，患者在摄入时和治疗4周后的S100B浓度均有所增加。治疗4周后，最初增加的P3-潜伏期正常化，P2-潜伏期显著降低，尽管只有初始S100B水平明显升高的患者（健康对照组的平均值加2 SD）。结论：重度抑郁症患者S100B水平适度升高的神经再生活性可能是抗抑郁治疗期间重度抑郁症患者ERP延长参数降低的一个因素。
Rationale: S100B is an astrocytic, calcium-binding protein which in nanomolar concentrations has neuroprotective and regenerating effects on neurons and glial cells. Increased levels have been shown to be positively correlated with therapeutic response in major depression. Event- related potentials ( ERP) have been reported to be impaired in depressed patients.Objectives: The aim of our study was to assess the relationship between S100B and visually evoked ERP in depression.Methods: ERP and S100B serum concentration were studied in 18 patients with major depression, before and after 4 weeks of antidepressant treatment.Results: The S100B concentration in patients was increased at intake and after 4 weeks of treatment compared to healthy controls. Initially increased P3- latency normalized and P2- latency significantly decreased after 4 weeks of treatment, although only in patients with clearly elevated initial S100B levels ( mean plus 2 SD of the healthy controls).Conclusion: The neuroregenerative activity of moderately increased S100B levels in major depression might be a factor contributing to a decrease of prolonged ERP parameters in major depression during antidepressant treatment.