Aminoxidation of Arenethiols to N-Chloro-N-sulfonyl Sulfinamides
Aminoxidation of Arenethiols to N-Chloro-N-sulfonyl Sulfinamides
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芳烃硫醇氨氧化生成 N-氯-N-磺酰亚磺酰胺
DOI：
10.1021/acs.joc.6b00261
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发表时间：
2016
影响因子：
3.6
通讯作者：
Xu Jiaxi
中科院分区：
文献类型：
--
作者：
Yang Zhanhui;Xu Wei;Wu Quyue;Xu Jiaxi
本发明公开了一种简单有效的合成N-氯-N-磺酰基亚磺酰胺的方法，该方法是在温和的水溶液条件下，通过芳硫醇的直接氨氧化，将氧代和氨基成对地安装在芳硫醇的硫原子上。该产品主要开发为亚磺酰化试剂，将格氏试剂转化为亚砜，并作为胺化试剂将仲胺转化为肼衍生物。
A simple and efficient method to synthesizeN-chloro-N-sulfonylsulfinamides by the direct aminoxidation of arenethiols under aqueous and mild conditions is disclosed, geminally installing the oxo and amino groups on the sulfur atom of arenethiols. The products have been primarily developed as sulfinylation reagents to convert Grignard reagents into sulfoxides, and as amination reagents to convert secondary amines into hydrazine derivatives.