Supplementation with vitamin B12 decreases homocysteine and methylmalonic acid but also serum folate in patients with end-stage renal disease
Supplementation with vitamin B12 decreases homocysteine and methylmalonic acid but also serum folate in patients with end-stage renal disease
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DOI：
10.1016/s0026-0495(99)90062-8
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发表时间：
1999-05-01
影响因子：
9.8
通讯作者：
Luley, C
中科院分区：
文献类型：
--
作者：
Dierkes, J;Domröse, U;Luley, C
高同型半胱氨酸血症常见于终末期肾病（ESRD）患者。补充叶酸或叶酸、维生素B-12和维生素B-6的组合可降低血浆总同型半胱氨酸（tHcy）浓度。在ESRD患者中单独补充维生素B-12的研究尚未发表。在这项研究中，我们研究了静脉注射氰钴胺（1 mg/wk，持续4周）对血清钴胺素浓度低的ESRD患者（N = 14）的影响。
Hyperhomocysteinemia is frequently found in patients with end-stage renal disease (ESRD). Plasma total homocysteine (tHcy) concentrations may be reduced by supplementation with folic acid or combinations of folic acid, vitamin B-12, and vitamin B-6. Supplementation studies with vitamin B-12 alone in patients with ESRD have not yet been published. In this study, we investigated the effects of intravenous injection of cyanocobalamin (1 mg/wk for 4 weeks) in ESRD patients (N = 14) with low serum cobalamin concentrations (