Redox regulation of apoptotic cell death
Redox regulation of apoptotic cell death
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DOI：
10.1002/biof.5520080101
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发表时间：
1998-01-01
期刊：
影响因子：
6
通讯作者：
Orrenius, S
中科院分区：
文献类型：
--
作者：
Hampton, MB;Orrenius, S
细胞凋亡是细胞死亡的一种特殊形式，可由多种信号和病理生理条件（包括氧化应激）触发。半胱氨酸蛋白酶的半胱氨酸蛋白酶家族成员的激活是细胞凋亡死亡程序中的一个关键事件。作为半胱氨酸蛋白酶，半胱天冬酶对氧化还原敏感。细胞的状态，并且它们的活性被过度的氧化应激阻断。因此，细胞内氧化还原状态的改变可以触发或阻断凋亡死亡程序，这取决于氧化应激的严重程度。
Apoptosis is a special form of cell death, which can be triggered by a variety of signals and pathophysiological conditions, including oxidative stress. Activation of members of the caspase family of cysteine proteases is a crucial event in the apoptotic death program. Being cysteine proteases, the caspases are sensitive to the redox. status of the cell, and their activity is blocked by excessive oxidative stress. Thus, alterations of intracellular redox status may either trigger or block the apoptotic death program, depending on the severity of the oxidative stress.