Protein families in multicellular organisms
Protein families in multicellular organisms
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DOI：
10.1016/s0959-440x(99)80055-4
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发表时间：
1999-06-01
影响因子：
6.8
通讯作者：
Bork, P
中科院分区：
文献类型：
--
作者：
Copley, RR;Schultz, J;Bork, P
秀丽隐杆线虫的完整序列包含承担单细胞核心生物学过程所需的遗传机制。然而，基因组也编码与多细胞相关的蛋白质，以及其他与系统发育广泛的家族的谱系特异性扩展相关的蛋白质，以及更多在非线虫中不存在的蛋白质。正在进行的分析已经开始阐明人类蛋白质和由多细胞蠕虫和单细胞酵母基因组编码的蛋白质之间的异同，这对于确定在系统发育上遥远的物种之间传递实验数据的可靠性至关重要。
The complete sequence of the nematode worm Caenorhabditis elegans contains the genetic machinery that is required to undertake the core biological processes of single cells. However, the genome also encodes proteins that are associated with multicellularity, as well as others that are lineage-specific expansions of phylogenetically widespread families and yet more that are absent in non-nematodes. Ongoing analysis is beginning to illuminate the similarities and differences among human proteins and proteins that are encoded by the genomes of the multicellular worm and the unicellular yeast, and will be essential in determining the reliability of transferring experimental data among phylogenetically distant species.