Impoverished descriptions of familiar routes in three cases of hippocampal/medial temporal lobe amnesia
Impoverished descriptions of familiar routes in three cases of hippocampal/medial temporal lobe amnesia
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DOI：
10.1016/j.cortex.2015.06.008
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发表时间：
2015-10-01
期刊：
影响因子：
3.6
通讯作者：
Rosenbaum, R. Shayna
中科院分区：
文献类型：
--
作者：
Herdman, Katherine A.;Calarco, Nauona;Rosenbaum, R. Shayna
最近的研究挑战了海马体功能在空间记忆中的经典理论，发现海马体可能是很久以前学习的环境的详细表征所必需的，但不是为了记忆足以在这些环境中导航的要点或示意图方面(Rosenbaum等人，2000；Rosenbaum，Winocur，Binns和Moscovitch，2012)。我们的目的是通过在路线描述任务和心理导航任务中对三例海马体内侧颞叶(MTL)健忘症患者的详细环境和熟悉环境的图示表示进行测试，以进一步探讨它们之间的区别。健忘症病例可以描述已知的、想象的路线上的基本方向，估计著名地标之间的距离和方向，并生成布局准确的草图，暗示完整的示意图。然而，他们的路线描述缺乏丰富的细节，加上贫穷的示意图和糟糕的地标识别，这一发现证实了之前的发现，即详细的表示是依赖于海马体的。(C)2015爱思唯尔有限公司。保留所有权利。
Recent research has challenged classic theories of hippocampal function in spatial memory with findings that the hippocampus may be necessary for detailed representations of environments learned long ago, but not for remembering the gist or schematic aspects that are sufficient for navigating within those environments (Rosenbaum et al., 2000; Rosenbaum, Winocur, Binns, & Moscovitch, 2012). We aimed to probe further distinctions between detailed and schematic representations of familiar enVironments in three cases of hippocampaVmedial temporal lobe (MTL) amnesia by testing them on a route description task and mental navigation tasks that assess the identity and location of landmarks, and distances and directions between them. The amnesic cases could describe basic directions along known, imagined routes, estimate distance and direction between well-known landmarks, and produce sketch maps with accurate layouts, suggestive of intact schematic representations. However, findings that their route descriptions lack richness of detail, along with impoverished sketch maps and poor landmark recognition, substantiates previous findings that detailed representations are hippocampus-dependent. (C) 2015 Elsevier Ltd. All rights reserved.