Disease activity and risk of lymphoma in patients with rheumatoid arthritis:: nested case-control study
Disease activity and risk of lymphoma in patients with rheumatoid arthritis:: nested case-control study
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DOI：
10.1136/bmj.317.7152.180
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发表时间：
1998-07-18
影响因子：
--
通讯作者：
Klareskog, L
中科院分区：
文献类型：
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作者：
Baecklund, E;Ekbom, A;Klareskog, L
类风湿性关节炎等炎症性疾病及其治疗可能与癌症有致病关系。这种可能的关系对风湿病患者的护理和控制也有实际意义。类风湿性关节炎患者患淋巴瘤的风险增加。1 2这种联系的潜在机制尚不清楚。我们进行了一项研究，以评估疾病活动、风湿病的各种继发性表现和药物治疗在多大程度上是类风湿性关节炎患者发生淋巴瘤的独立危险因素。
Inflammatory diseases such as rheumatoid arthritis and their treatment may have a pathogenic relation with cancer. The possible relation also has practical implications for the care and control of rheumatic patients.Patients with rheumatoid arthritis have been shown to have an increased risk of developing lymphomas. 1 2 The underlying mechanisms for this association are unclear. We performed a study to assess to what extent disease activity, various secondary manifestations of rheumatic disease, and drug treatment were independent risk factors for the development of lymphoma in patients with rheumatoid arthritis.