REGIONAL DISTRIBUTION OF INSPIRED GAS IN LUNG
REGIONAL DISTRIBUTION OF INSPIRED GAS IN LUNG
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DOI：
10.1152/jappl.1966.21.3.749
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发表时间：
1966-01-01
影响因子：
3.3
通讯作者：
KANEKO, K
中科院分区：
文献类型：
--
作者：
MILICEMILI, J;HENDERSON, JA;KANEKO, K
使用 Xe133 对 9 名坐着的正常男性测量了不同肺容量下不同区域肺部的扩张情况。上肺区的区域体积（表示为最大吸气时每个区域的体积的分数）总是大于下肺区。当肺容量从残余容量增加到约20%肺活量时，上肺区域的局部肺容量变化（表示为最大吸气时每个区域的体积的分数）大于下肺区域，而在较高肺容量时则相反。根据这些数据，可以系统地描述不同吸气前肺容量和潮气量对通气区域分布的影响。有证据表明，正常肺通气分布不均匀是胸膜压区域差异的结果。
The expansion of different regions of the lungs at various lung volumes was measured in 9 seated normal men, using Xe133. Regional volumes (expressed as a fraction of the volume of each region at maximal inspiration) were always greater in upper than in lower lung zones. When lung volume was increased from residual volume to about 20% vital capacity, the changes in regional lung volume (expressed as a fraction of the volume of each region at maximal inspiration) were greater in upper than in lower lung regions, whereas the opposite was true at higher lung volumes. From these data it was possible to describe systematically the effect on regional distribution of ventilation of varying both preinspiratory lung volume and tidal volume. Evidence is presented suggesting that the uneven distribution of ventilation in the normal lung is the consequence of regional differences in pleural pressure.