Bone remodelling in humans is load-driven but not lazy
Bone remodelling in humans is load-driven but not lazy
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DOI：
10.1038/ncomms5855
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发表时间：
2014-09-01
影响因子：
16.6
通讯作者：
van Rietbergen, Bert
中科院分区：
文献类型：
--
作者：
Christen, Patrik;Ito, Keita;van Rietbergen, Bert
在骨重塑过程中，骨细胞被认为分别在高负荷和低负荷的部位添加和移除组织。为了预测骨重塑，有人建议在组织负荷的一定阈值以下移除骨，并在这些阈值以上添加骨，在这些阈值内，称为“惰性区”，骨量不会发生净变化。动物实验将机械载荷与骨密度或微观结构的变化联系起来，支持负载适应性骨重塑，而在人类中，这种关系在微观尺度上的证据仍然缺乏。利用新的高分辨率CT成像技术和计算方法，我们量化了人体微结构变化和生理组织负荷。在这里，我们表明，健康绝经后妇女的骨重塑位点与组织负荷密切相关，遵循线性关系，没有“懒惰区”，为人类负荷驱动的重塑提供了无偏倚的证据。这表明人类和动物的骨骼都以类似的方式对负荷诱导的重塑做出反应。
During bone remodelling, bone cells are thought to add and remove tissue at sites with high and low loading, respectively. To predict remodelling, it was proposed that bone is removed below and added above certain thresholds of tissue loading and within these thresholds, called a 'lazy zone', no net change in bone mass occurs. Animal experiments linking mechanical loading with changes in bone density or microstructure support load-adaptive bone remodelling, while in humans the evidence for this relationship at the micro-scale is still lacking. Using new high-resolution CT imaging techniques and computational methods, we quantify microstructural changes and physiological tissue loading in humans. Here, we show that bone remodelling sites in healthy postmenopausal women strongly correlate with tissue loading following a linear relationship without a 'lazy zone' providing unbiased evidence for load-driven remodelling in humans. This suggests that human and animal bones both react to loading induced remodelling in a similar fashion.