Brain Response of Major Depressive Disorder Patients to Emotionally Positive and Negative Music
Brain Response of Major Depressive Disorder Patients to Emotionally Positive and Negative Music
复制标题
重度抑郁症患者的大脑对情绪积极和消极音乐的反应
DOI：
10.1007/s12031-022-02061-3
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发表时间：
2022-08-25
影响因子：
3.1
通讯作者：
Li, Ying
中科院分区：
文献类型：
--
作者：
Deng, Jin;Chen, Yuewei;Li, Ying
抑郁症的特点是情绪调节能力差，难以摆脱情绪痛苦的影响，但这些症状背后的神经调节机制尚不清楚。本研究探讨了音乐刺激时，与从未抑郁（ND）的对照组相比，重度抑郁症（MDD）参与者的情绪状态相关反应的神经机制。提出了一种基于支持向量机递归特征消除（SVM-RFE）和随机森林算法（RF）的两级特征选择方法，用于情感识别脑区（ERBR）的筛选。在此基础上，采用双样本t检验对功能连接性（FC）的差异进行了系统分析。结果表明，在15个情感障碍的ERBR中，ND被试表现出8对FC，其中积极情感音乐刺激（pEMS）与消极情感音乐刺激（nEMS）之间存在显著性差异，而MDD被试表现出1对FC存在显著性差异。抑郁症患者对积极情绪和消极情绪的反应模糊，可能是由于情绪认知和调节障碍所致。此外，在pEMS下MDDs和NDs之间的FC没有显著差异，但在nEMS下检测到两组之间的显著差异（p < 0.01），揭示了对MDD阴性状态的“偏倚”。目前的研究可能有助于更好地理解从正常到抑郁症的异常演变，并为pEMS在抑郁症正式治疗中的应用提供信息。
Depression is characterized by poor emotion regulation that makes it difficult to escape the effects of emotional pain, but the neuromodulation behind these symptoms is still unclear. This study investigated the neural mechanism of emotional state-related responses during music stimuli in participants with major depressive disorder (MDD) compared to never-depressed (ND) controls. A novel two-level feature selection method, integrating recursive feature elimination based on support vector machine (SVM-RFE) and random forest algorithm (RF), was proposed to screen emotional recognition brain regions (ERBRs). On this basis, the differences of functional connectivity (FC) were systematically analyzed by two-sample t-test. The results demonstrate that ND participants show eight pairs of FCs with a significant difference between positive emotional music stimuli (pEMS) versus negative emotional music stimuli (nEMS) in 15 ERBRs of MDD, but the participants with MDD show one pair of significant difference in FC. The decreased number reflects the fuzzy response to positive and negative emotions in MDD, which appears to arise from obstacle to emotional cognition and regulation. Furthermore, there was no significant difference in FC between MDDs and NDs under pEMS, but a significant difference was detected between the two groups under nEMS (p < 0.01), revealing a 'bias' against the negative state in MDD. The current study may help to better comprehend the abnormal evolution from normal to depression and inform the utilization of pEMS in formal treatment for depression.