13N-ammonia positron emission tomography-derived left-ventricular strain in patients after heart transplantation validated using cardiovascular magnetic resonance feature tracking as reference
13N-ammonia positron emission tomography-derived left-ventricular strain in patients after heart transplantation validated using cardiovascular magnetic resonance feature tracking as reference
复制标题
使用心血管磁共振特征跟踪作为参考验证心脏移植后患者的 13N-氨正电子发射断层扫描衍生的左心室应变
DOI：
10.1007/s12149-021-01686-5
复制
发表时间：
2021
影响因子：
2.6
通讯作者：
Sakai Shuji
中科院分区：
文献类型：
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作者：
Kawakubo Masateru;Nagao Michinobu;Kikuchi Noriko;Yamamoto Atsushi;Nakao Risako;Matsuo Yuka;Kaneko Koichiro;Watanabe Eri;Sasaki Masayuki;Nunoda Shinichi;Sakai Shuji
目的心脏移植排斥反应可导致心脏移植物血管病（cardiac allograft vasculopathy，CAV）。13 N-氨正电子发射断层扫描（PET）可用于检测心脏移植物血管病（cardiac allograft vasculopathy，CAV），因为它可以评价心外膜血管和微血管。在这项研究中，我们评估了局部室壁运动的心脏移植患者使用我们的PET特异性功能跟踪（FT）算法的心肌应变计算和验证它使用心血管磁共振（CMR）FT strain as a reference.MethodsA共15心脏移植患者谁接受both 13 N-氨PET和CMR在3个月内进行了回顾性登记。选择左心室（LV）中间切片的短轴电影图像的相同层位和水平长轴电影图像的相同层位，用于两种模式分别测量周向应变（CS）和纵向应变（LS）。基于FT技术，通过在整个心动周期内半自动跟踪电影图像上的内膜轮廓来计算时间-应变曲线。将时间-应变曲线中的峰值定义为代表值。采用Pearson相关系数分析PET和CMR之间的CS和LS的相关性。结果PET和CMR之间的CS和LS具有良好的相关性（CS：r= 0.80;p< 0.01; LS：r= 0.87;p< 0.01）。观察到优秀的ICC（0.89和0.85）CS和LS来自PET.ConclusionsWe提出的第一个PET应变表现出良好的一致性与CMR应变和高再现性的测量。
ObjectiveHeart transplant rejection leads to cardiac allograft vasculopathy (CAV).13N-ammonia positron emission tomography (PET) can be useful in detecting CAV, as it can evaluate both epicardial vessels and microvasculature. In this study, we evaluated the regional wall motion in heart transplant patients using our PET-specific feature-tracking (FT) algorithm for myocardial strain calculation and validated it using a cardiovascular magnetic resonance (CMR) FT strain as a reference.MethodsA total of 15 heart transplant patients who underwent both13N-ammonia PET and CMR within 3 months were retrospectively enrolled. The same slice position of short-axis cine images of the middle slice of left ventricle (LV) and the same slice position of horizontal long-axis cine images were selected for the two modalities to measure the circumferential strain (CS) and longitudinal strain (LS), respectively. Based on the FT technique, time–strain curves were calculated by semi-automatic tracking of the endocardial contour on cine images throughout a cardiac cycle. The peak value in the time-strain curve was defined as the representative value. Correlations of CS and LS between PET and CMR were analyzed using Pearson correlation coefficients. The inter-modality error of strain measurements was evaluated using intraclass correlation coefficients (ICCs) with two-way random single measures.ResultsExcellent correlations of CS and LS between PET and CMR were observed (CS:r= 0.80;p< 0.01; LS:r= 0.87;p< 0.01). Excellent ICCs were observed (0.89 and 0.85) in CS and LS derived from PET.ConclusionsWe propose the first PET strain showing an excellent agreement with the CMR strain and high reproducibility in measurement.