An update on biomarkers of necrotizing enterocolitis
An update on biomarkers of necrotizing enterocolitis
复制标题
DOI：
10.1016/j.siny.2018.07.006
复制
发表时间：
2018-12-01
影响因子：
3
通讯作者：
Ng, Pak Cheung
中科院分区：
文献类型：
--
作者：
Ng, Pak Cheung
坏死性小肠结肠炎（NEC）仍然是一个毁灭性的外科急诊与高发病率和死亡率的早产儿。在过去的几年里，为了监测和诊断的目的，寻找NEC的新型生物标志物取得了缓慢但稳定的进展。这篇综述主要集中在最近的发现：不同类别的生物标志物在监测、早期诊断、预测严重程度和预后方面的临床应用；以及对病理生理机制的理解，作为寻找NEC“肠道相关特异性生物标志物”的基础。重要的下一步是与我们的工业合作伙伴合作开发即时检测，并发现新的和肠道相关的特异性生物标志物，这些生物标志物可用于常规临床环境中的NEC监测和早期诊断。
Necrotizing enterocolitis (NEC) remains a devastating surgical emergency with high morbidity and mortality in preterm infants. Slow but steady progress has been made in past years searching for novel biomarkers of NEC, for both surveillance and diagnostic purposes. This review primarily focuses on recent discoveries: clinical applications of different categories of biomarkers for surveillance, early diagnosis, and predicting severity and prognosis; and understanding of pathophysiological mechanisms as a basis to rationalize the search for 'gut-associated specific biomarkers' of NEC. An important next step is to collaborate with our industrial partners to develop point-of-care tests, and to discover novel and gut-associated specific biomarkers that can be used for surveillance and early diagnosis of NEC in routine clinical settings.