Changing patterns of cytomegalovirus seroprevalence among pregnant women in Norway between 1995 and 2009 examined in the Norwegian Mother and Child Cohort Study and two cohorts from Sor-Trondelag County: a cross-sectional study
Changing patterns of cytomegalovirus seroprevalence among pregnant women in Norway between 1995 and 2009 examined in the Norwegian Mother and Child Cohort Study and two cohorts from Sor-Trondelag County: a cross-sectional study
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DOI：
10.1136/bmjopen-2013-003066
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发表时间：
2013-01-01
期刊：
影响因子：
2.9
通讯作者：
Iversen, Ann-Charlotte
中科院分区：
文献类型：
--
作者：
Odland, Maria Lisa;Strand, Kristin M.;Iversen, Ann-Charlotte
目的：研究挪威孕妇巨细胞病毒（CMV）血清阳性率及相关危险因素。设计：横断面研究。设置：挪威母亲和儿童队列研究（MoBa），以及挪威Sor-Trondelag县孕妇的两个随机样本。参与者：研究组1为1000名孕妇，从MoBa（1999-2006）的46 127例妊娠中随机选择妊娠17/18周的孕妇。非挪威族裔妇女被排除在外。研究组2（n=1013从1995年）和3（n=979从2009年）是孕妇在12周的妊娠期从Sor-Trondelag County. Results措施：CMV血清阳性的血液样本从孕妇Norwegianwomen.Results：CMV-IgG抗体检测到59.9%和CMV-IgM抗体在1.3%的挪威孕妇在研究组1。来自挪威北部的妇女表现出更高的CMV-IgG血清阳性率（72.1%）比挪威南部的妇女（58.5%）（OR 1.83，95% CI 1.17至2.88）。低学历妇女CMV IgG阳性率（70.5%）高于高学历妇女（OR 2.20，95%CI 1.24 ~ 3.90）。1995年至2009年间，Sor-Trondelag县孕妇中CMV-IgG血清阳性率从63.1%上升至71.4%（研究组2和3; p
Objectives: To examine cytomegalovirus (CMV) seroprevalence and associated risk factors for CMV seropositivity in pregnant Norwegian women.Design: Cross-sectional study.Setting: The Norwegian Mother and Child Cohort Study (MoBa) in addition to two random samples of pregnant women from Sor-Trondelag County in Norway.Participants: Study group 1 were 1000 pregnant women, randomly selected among 46 127 pregnancies in the MoBa (1999-2006) at 17/18 week of gestation. Nonethnic Norwegian women were excluded. Study groups 2 (n=1013 from 1995) and 3 (n=979 from 2009) were pregnant women at 12 weeks of gestation from Sor-Trondelag County.Outcome measures: CMV seropositivity in blood samples from pregnant Norwegian women.Results: CMV-IgG antibodies were detected in 59.9% and CMV-IgM antibodies in 1.3% of pregnant Norwegian women in study group 1. Women from North Norway demonstrated a higher CMV-IgG seroprevalence (72.1%) than women from South Norway (58.5%) (OR 1.83, 95% CI 1.17 to 2.88). The CMV-IgG seroprevalence was higher among women with low education (70.5%) compared to women with higher education (OR 2.20, 95% CI 1.24 to 3.90). Between 1995 and 2009 the CMV-IgG seroprevalence increased from 63.1% to 71.4% in pregnant women from Sor-Trondelag County (study groups 2 and 3; p