Update on morphea Part I. Epidemiology, clinical presentation, and pathogenesis
Update on morphea Part I. Epidemiology, clinical presentation, and pathogenesis
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DOI：
10.1016/j.jaad.2010.05.045
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发表时间：
2011-02-01
影响因子：
13.8
通讯作者：
Werth, Victoria P.
中科院分区：
文献类型：
--
作者：
Fett, Nicole;Werth, Victoria P.
吗啡，也被称为局限性硬皮病，是一种罕见的皮肤和底层组织纤维性疾病。由于没有硬指症、雷诺现象和甲皱毛细血管改变，吗啡与系统性硬化症是有区别的。患有吗啡的患者通常有全身症状，如身体不适、疲劳、关节痛和肌痛，以及自身抗体血清阳性。然而，吗啡的参与几乎一致地局限于来自中胚层的组织。吗啡的潜在发病机制目前还不完全清楚，但最终导致胶原生成和破坏的失衡。(J am Acad Dermatol 2011；：217-28。)
Morphea, also known as localized scleroderma, is a rare fibrosing disorder of the skin and underlying tissues. Morphea is differentiated from systemic sclerosis based on the absence of sclerodactyly, Raynaud phenomenon, and nailfold capillary changes. Patients with morphea commonly have systemic symptoms, such as malaise, fatigue, arthralgias, and myalgias, as well as positive autoantibody serologies. However, involvement of morphea is almost uniformly limited to those tissues derived from the mesoderm. The underlying pathogenesis of morphea is incompletely understood at this time, but ultimately results in an imbalance of collagen production and destruction. (J Am Acad Dermatol 2011;64:217-28.)