Fusobacterium nucleatum load in MSI colorectal cancer subtypes
Fusobacterium nucleatum load in MSI colorectal cancer subtypes
复制标题
MSI 结直肠癌亚型中的具核梭杆菌载量
DOI：
10.1007/s10147-022-02218-5
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发表时间：
2022
影响因子：
3.3
通讯作者：
Horiguchi Shin-ichiro
中科院分区：
文献类型：
--
作者：
Ono Tomoyuki;Yamaguchi Tatsuro;Takao Misato;Kojika Ekumi;Iijima Takeru;Horiguchi Shin-ichiro
核梭杆菌感染可在微卫星不稳定性(MSI)背景下导致结直肠癌(CRC)的发生。然而，到目前为止，两国之间的关系。核载量和微卫星不稳定性结直肠癌亚型尚未阐明。94例MSI CRC患者中，32例为Lynch综合征遗传性MSI CRC，62例为散发性MSI CRC，其余85例为微卫星稳定(MSS)型。F.的关联。结果179例结直肠癌患者中有158例(88.3%)为F。核仁呈阳性。很高。遗传性、散发性和多发性结直肠癌的核载量分别为84.4%(27/32)、96.8%(60/62)和83.5%(71/85)(P= 0.024)。在临床病理特征方面，本组病例具有较高的临床表现。女性结直肠癌、右侧结直肠癌、BRAFV600E结直肠癌、CpG岛甲基化表型阳性结直肠癌和微卫星结直肠癌与核载量显著相关(P= 0.008，P= 0.015，P= 0.007，P= 0.006，P<； 0.001)。但临床病理特征差异无统计学意义。无肿瘤深度的遗传性和散发性MSI癌之间的核载量。遗传性MSI结直肠癌的核负荷高于MSS结直肠癌和散发性MSI结直肠癌。这些发现可能有助于通过适当的干预预防遗传性MSI CRC中的CRC。
BackgroundFusobacterium nucleatum(F. nucleatum) infection may lead to colorectal cancer (CRC) development in the context of microsatellite instability (MSI). To date, however, the relationship betweenF. nucleatumload and MSI CRC subtypes has not been clarified.MethodsOne hundred seventy-nine consecutive patients with CRC were enrolled in the present study. In 94 patients with MSI CRC, 32 had hereditary MSI CRC from Lynch syndrome, 62 had sporadic MSI CRC, while the remaining 85 had microsatellite stable (MSS) CRC. The association of theF. nucleatumload with each CRC subtype and the patients’ clinicopathological characteristics was examined.ResultsOf the 179 patients with CRC, 158 (88.3%) wereF. nucleatum-positive. A highF. nucleatumload was found in 84.4% (27/32), 96.8% (60/62), and 83.5% (71/85) of the patients with hereditary MSI CRC, sporadic MSI CRC, and MSS CRC, respectively (P= 0.024). In terms of clinicopathological features, a highF. nucleatumload was significantly associated with female, right-sided CRC,BRAFV600E, CpG island methylator phenotype-positive CRC, and MSI CRC (P= 0.008,P= 0.015,P= 0.007,P= 0.006, andP< 0.001, respectively). However, the clinicopathological characteristics did not differ significantly byF. nucleatumload between hereditary and sporadic MSI CRCs without tumor depth.ConclusionsTheF. nucleatumload was higher in hereditary MSI CRC than in MSS CRC as well as sporadic MSI CRC. These findings may contribute to preventing CRC in hereditary MSI CRC through appropriate intervention.
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影响因子：
10.5
作者：
Brennan CA;Garrett WS
通讯作者：
Garrett WS
影响因子：
11.4
作者：
Zhenwei Dai;O. Coker;Geicho Nakatsu;William K. K. Wu-William-K.-K.-Wu-2110027461;Liuyang Zhao;Zigui Chen;F. Chan;K. Kristiansen;J. Y. Sung;S. Wong;Jun Yu
通讯作者：
Zhenwei Dai;O. Coker;Geicho Nakatsu;William K. K. Wu-William-K.-K.-Wu-2110027461;Liuyang Zhao;Zigui Chen;F. Chan;K. Kristiansen;J. Y. Sung;S. Wong;Jun Yu
影响因子：
4.1
作者：
Ogino, Shuji;Kawasaki, Takako;Fuchs, Charles S.
通讯作者：
Fuchs, Charles S.
影响因子：
3.9
作者：
Coxhead, JM;Williams, EA;Mathers, JC
通讯作者：
Mathers, JC
影响因子：
28.4
作者：
Mima K;Sukawa Y;Nishihara R;Qian ZR;Yamauchi M;Inamura K;Kim SA;Masuda A;Nowak JA;Nosho K;Kostic AD;Giannakis M;Watanabe H;Bullman S;Milner DA;Harris CC;Giovannucci E;Garraway LA;Freeman GJ;Dranoff G;Chan AT;Garrett WS;Huttenhower C;Fuchs CS;Ogino S
通讯作者：
Ogino S