Relation between amygdala structure and function in adolescents with bipolar disorder.
Relation between amygdala structure and function in adolescents with bipolar disorder.
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DOI：
10.1097/chi.0b013e31819f6fbc
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发表时间：
2009-06
影响因子：
13.3
通讯作者：
Blumberg HP
中科院分区：
文献类型：
--
作者：
Kalmar JH;Wang F;Chepenik LG;Womer FY;Jones MM;Pittman B;Shah MP;Martin A;Constable RT;Blumberg HP
先前的研究支持双相情感障碍（BD）青少年杏仁核体积减少和对情绪刺激的反应升高。在本研究中，结构和功能磁共振成像（MRI）扫描，在同一个神经成像会议，以检查杏仁核结构与功能的关系，在青少年BD。我们假设杏仁核体积与杏仁核对情绪刺激的反应呈负相关，因此杏仁核体积最小的BD参与者将表现出最高的杏仁核反应。51例青少年[21例BDI，30例健康对照（HC）青少年，年龄10-18岁]接受了结构和功能MRI扫描。比较两组间杏仁核体积（N=49）和情绪面孔处理过程中的信号变化（N=44），并在BD组（N=16）内检查结构-功能相关性。患有BD的青少年表现出杏仁核体积减少（p= 0.009）和杏仁核对情绪面孔的反应增加（p= 0.043）。诊断和情绪类型之间没有显着的相互作用。杏仁核体积和情绪面孔处理过程中的激活之间存在显著的负相关（r=-0.54，p= 0.029）。BD青少年的杏仁核体积减少和对情绪刺激的反应增加与以前的报道一致。这项研究代表了第一份报告，据我们所知，在同一个青少年BD样本的两个结果，并支持杏仁核的结构功能的关系，其特征在于体积和情绪刺激的反应之间的负相关。这一初步发现需要复制，并提出了一个可能的病理生理学之间的联系，杏仁核结构异常和情绪刺激的反应在BD。
Previous study supports the presence of reduced volume and elevated response to emotional stimuli in amygdala in adolescents with bipolar disorder (BD). In the present study, structural and functional magnetic resonance imaging (MRI) scans were obtained during the same neuroimaging session in order to examine amygdala structure-function relationships in adolescents with BD. We hypothesized that amygdala volume would be inversely associated with amygdala response to emotional stimuli, such that BD participants with the smallest amygdala volumes would exhibit the highest amygdala response. 51 adolescents [21 with BDI, 30 healthy comparison (HC) adolescents, ages 10-18] underwent structural and functional MRI scans. Amygdala volume (N=49) and signal change (N=44) during emotional face processing were compared between groups and structure-function correlations were examined within the BD group (N=16). Adolescents with BD displayed decreased amygdala volume (p=.009) and increased amygdala response to emotional faces (p=.043). There was no significant interaction between diagnosis and emotion type. A significant inverse association between amygdala volume and activation during emotional face processing was observed (r=−.54, p=.029). Decreased volume and increased response to emotional stimuli in amygdala in BD adolescents are consistent with previous reports. This study represents the first report, to our knowledge, of the two findings in the same adolescent BD sample and supports an amygdala structure-function relationship characterized by an inverse association between volume and response to emotional stimuli. This preliminary finding requires replication and suggests a possible pathophysiological link between abnormalities in amygdala structure and response to emotional stimuli in BD.