Leptin and norepinephrine plasma concentrations during glucose loading in normotensive and hypertensive obese women
Leptin and norepinephrine plasma concentrations during glucose loading in normotensive and hypertensive obese women
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DOI：
10.1016/s0895-7061(01)01288-2
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发表时间：
2001-07-01
影响因子：
3.2
通讯作者：
Buemi, M
中科院分区：
文献类型：
--
作者：
Corica, F;Corsonello, A;Buemi, M
我们进行这项研究，以调查是否在口服葡萄糖耐量试验（OGTT）期间血浆葡萄糖，胰岛素和去甲肾上腺素浓度的变化与血压正常和高血压肥胖妇女血浆瘦素水平的变化。在基线和OGTT期间对血压正常的女性的血浆胰岛素、葡萄糖、去甲肾上腺素和瘦素浓度进行评估（NT-Ob，N = 24，平均年龄38.3 ± 1.8岁，体重指数[BMI] 37.9 ± 1.1 kg/m2）和高血压（HT-Ob，N = 25，平均年龄37.7 ± 1.9岁，BMI 39.4 ± 1.3 kg/m2）肥胖女性，以及一组正常体重女性（对照组，N = 20，平均年龄38.3 ± 1.3岁，BMI 23.1 ± 0.4 kg/m2）。OGTT引起的血浆瘦素浓度显着增加，在NT-Ob和HT-Ob组，而没有这样的变化是在对照组中检测。血浆瘦素曲线下面积（AUC）与去甲肾上腺素AUC在NT-Ob（r = 0.73，P = 0.001）和HT-Ob（r = 0.74，P = 0.001）组中均显示直接相关，在多变量分析中仍可检测到（分别为P = 0.014和P = 0.017）。我们的研究证实，葡萄糖负荷增加循环瘦素浓度在肥胖妇女，并证明存在的关联瘦素和去甲肾上腺素的变化在OGTT在正常血压和高血压肥胖妇女。我们推测，这种关联可能反映了缺乏瘦素抑制的儿茶酚胺或直接瘦素诱导的交感神经激活。这些发现表明，瘦素可能与肥胖妇女的血压调节有关。(C)2001年美国高血压杂志有限公司
We performed this study to investigate whether changes in plasma glucose, insulin, and norepinephrine concentrations during an oral glucose tolerance test (OGTT) are associated with changes in plasma leptin levels in normotensive and hypertensive obese women. Plasma insulin, glucose, norepinephrine, and leptin concentrations were evaluated at the baseline and during OGTT in normotensive women (NT-Ob, N = 24, mean age 38.3 +/- 1.8 years, body mass index [BMI] 37.9 +/- 1.1 kg/m(2)) and hypertensive (HT-Ob, N = 25, mean age 37.7 +/- 1.9 years, BMI 39.4 +/- 1.3 kg/m(2)) obese women, and in a group of normal-weight women (controls, N = 20, mean age 38.3 +/-: 1.3 years, BMI 23.1 +/- 0.4 kg/m(2)). The OGTT caused a significant increase in plasma leptin concentrations in both NT-Ob and HT-Ob groups, whereas no such change was detectable in control subjects. Area under curve (AUC) for plasma leptin showed a direct correlation with norepinephrine AUC in both NT-Ob (r = 0.73, P = .001) and HT-Ob (r = 0.74, P = .001) group, which was still detectable in multivariate analysis (P = .014 and P = .017, respectively). Our study confirms that glucose loadings increases circulating leptin concentrations in obese women, and demonstrates the existance of an association between leptin and norepinephrine changes during OGTT in both normotensive and hypertensive obese women. We hypothesize that this association may reflect the lack of leptin suppression by catecholamines or a direct leptin-induced sympathoactivation. These findings suggest that leptin could be relevant in the regulation of blood pressure in obese women. (C) 2001 American Journal of Hypertension, Ltd.