Quantitative 1H NMR. Development and potential of an analytical method: an update.

Quantitative 1H NMR. Development and potential of an analytical method: an update.
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DOI:
10.1021/np200993k
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发表时间:
2012-04-27
影响因子:
5.1
通讯作者:
Lankin DC
Lankin DC
中科院分区:
生物学2区
文献类型:
--
作者:
Pauli GF;Gödecke T;Jaki BU;Lankin DC

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本文综述了从2004年中到2011年底的文献,继续了以前的文献综述定量1H NMR(qHNMR)方法及其在天然产物(NPs)分析中的应用。qHNMR的最大优点之一是其具有外部校准的准确功能,不需要相同的参考物质,经过适当验证的高精密度和准确度,以及同时定量多种分析物的能力。由于纳入了170多个新的参考文献,这篇更新的综述总结了丰富的详细经验证据和新开发的方法,支持qHNMR作为天然产物和其他研究领域的有价值和无偏见的分析工具。
Covering the literature from mid-2004 until the end of 2011, this review continues a previous literature overview on quantitative 1H NMR (qHNMR) methodology and its applications in the analysis of natural products (NPs). Among the foremost advantages of qHNMR is its accurate function with external calibration, the lack of any requirement for identical reference materials, a high precision and accuracy when properly validated, and an ability to quantitate multiple analytes simultaneously. As a result of the inclusion of over 170 new references, this updated review summarizes a wealth of detailed experiential evidence and newly developed methodology that supports qHNMR as a valuable and unbiased analytical tool for natural product and other areas of research.
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