Characteristics of Mpox Infections in Louisiana in the 2022 Outbreak.
Characteristics of Mpox Infections in Louisiana in the 2022 Outbreak.
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路易斯安那州 2022 年爆发的 Mpox 感染特征。
DOI：
10.1089/aid.2023.0011
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发表时间：
2023
影响因子：
1.5
通讯作者：
Clement,MeredithE
中科院分区：
文献类型：
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作者：
Essajee,NabilM;Oddo-Moise,Hope;Hagensee,MichaelE;Lillis,RebeccaA;Maffei,Joanne;Butler,Isolde;Lovett,Aish;Sokol,Theresa;Clement,MeredithE
2022年，路易斯安那州爆发的麻疹病例被限制在300万例，考虑到该州艾滋病和其他性传播感染（sti）的高发率，这可能是一个意想不到的结果。我们的目标是描述新奥尔良地区两个卫生中心内的当地疫情，并与路易斯安那州卫生部合作提供额外的全州数据。我们审查了2022年7月至11月新奥尔良两个当地卫生中心的麻疹检测呈阳性的人的图表，这两个卫生中心加起来占当地病例的一半。我们提取了HIV状态、免疫功能[CD4计数、病毒载量（VL）]、抗逆转录病毒治疗方案、感染症状和严重程度、疫苗接种状况以及是否使用了替可韦莫的数据。我们提供了与全州数据（2022年7月至2023年1月）相关的本地数据。在我们审查了图表的103个网络个体中，96个（93%）被确定为男性，52个（50%）为黑人，69个（67%）患有HIV，其中12个（17%）HIV未控制（CD4 < 200 cells/mm3或VL bb0 200 copies/mL）。最常见的症状是皮疹（n= 71, 69%）、发热（n= 36, 35%）和直肠疼痛（n= 33, 32%）。在6名（6%）住院患者中，4名（67%）是艾滋病毒感染者（PWH）。2例因严重m痘感染住院，就诊时病变bb100；两人均为PWH，其中一人感染不受控制。在整个州，已经发现了307例病例，24例住院治疗。在住院患者中，18例（75%）为PWH，其中9例（50%）为HIV未控制患者。来自性传播感染和艾滋病毒/艾滋病高发州路易斯安那州的人口统计数据与先前描述2022年麻疹暴发的报告一致。我们的研究结果有助于积累艾滋病毒相关免疫功能低下患者感染严重程度的数据。
The 2022 outbreak of mpox in Louisiana was limited to just >300 cases, perhaps an unexpected outcome given the state's high rates of HIV and other sexually transmitted infections (STIs). We aimed to describe the local outbreak within two health centers in the New Orleans region, partnering with the Louisiana Department of Health to offer additional statewide data. We reviewed charts of persons testing positive for mpox in New Orleans from July to November 2022 at two local health centers that together accounted for half of local cases. We abstracted data on HIV status, immune function [CD4 count, viral load (VL)], antiretroviral therapy regimen, symptoms and severity of infection, vaccination status, and whether tecovirimat was administered. We present local data relative to statewide data (July 2022–January 2023). Of 103 individuals in our network for whom charts were reviewed, 96 (93%) identified as male, 52 (50%) were Black, and 69 (67%) had HIV, including 12 (17%) with uncontrolled HIV (CD4 < 200 cells/mm3or VL >200 copies/mL). The most common presenting symptoms were rash (n= 71, 69%), fever (n= 36, 35%), and rectal pain (n= 33, 32%). Of six (6%) patients hospitalized, four (67%) were persons with HIV (PWH). Two were hospitalized for severe mpox infection with >100 lesions at presentation; both were PWH, and one had uncontrolled infection. Across the state, 307 cases have been identified and 24 have been hospitalized. Of those hospitalized, 18 (75%) were PWH, including 9 (50%) with uncontrolled HIV. The demographic data from Louisiana, a state with high prevalence of STIs and HIV/AIDS, are consistent with prior reports describing the 2022 mpox outbreak. Our results contribute to accumulating data on the severity of infection in individuals with HIV-related immunocompromise.