Prophylactic effect of dietary seaweed fucoidan against enteral prion infection
Prophylactic effect of dietary seaweed fucoidan against enteral prion infection
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DOI：
10.1128/aac.00917-06
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发表时间：
2007-06-01
影响因子：
4.9
通讯作者：
Iha, Masahiko
中科院分区：
文献类型：
--
作者：
Doh-ura, Katsumi;Kuge, Tomoko;Iha, Masahiko
感染后 6 天口服海藻褐藻糖胶可延缓肠道感染瘙痒症小鼠的疾病发作，但在感染前口服则不然。这种效果在测试的岩藻依聚糖剂量范围内没有改变，并且在饲料中浓度为 2.5% 或更低时似乎达到最大水平。每日摄入岩藻依聚糖可能可以预防因摄入受朊病毒污染的物质而引起的朊病毒疾病，但其药理学仍有待进一步评估。
Dietary seaweed fucoidan delays the onset of disease of enterally infected mice with scrapie when given orally for 6 days after infection, but not when given before the infection. This effect was not modified at a tested fucoidan dose range and appeared to reach the maximum level at a concentration of 2.5% or less in feed. Daily uptake of fucoidan might be prophylactic against prion diseases caused by ingestion of prion-contaminated materials, although further evaluation of its pharmacology remains to be done.