Impaired Sleep Predicts Cognitive Decline in Old People: Findings from the Prospective KORA Age Study
Impaired Sleep Predicts Cognitive Decline in Old People: Findings from the Prospective KORA Age Study
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DOI：
10.5665/sleep.5352
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发表时间：
2016-01-01
期刊：
影响因子：
5.6
通讯作者：
Ladwig, Karl-Heinz
中科院分区：
文献类型：
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作者：
Johar, Hamimatunnisa;Kawan, Rasmila;Ladwig, Karl-Heinz
研究目的：为了探讨睡眠相关的特征和认知变化之间的关联超过3年的后续行动在aged population.Methods：睡眠特征和协变量进行了评估，在基线标准化的采访和临床检查的人口为基础的KORA年龄研究（n = 740，平均年龄= 75岁）。结果：613例受试者中，82.83%（n = 613）认知功能正常，13.51%（n = 100）轻度认知功能障碍（MCI），3.64%（n = 27）疑似痴呆。在广义线性回归模型中，考虑了三种不同模式的睡眠不良（难以启动[DIS]或维持睡眠[DMS]，白天嗜睡[DS]或睡眠持续时间）对认知评分变化的影响，并对潜在混杂因素进行了调整。与无DMS的个体相比，有DMS的个体的认知能力下降更明显（β = 1.33，95%CI = 0.41-2.24，P < 0.001）。然而，DMS的预测能力仅在认知正常的个体和基线时未受损的受试者中显着。睡眠时间延长会增加认知功能受损老年人认知功能下降的风险（β = 1.86，95%CI = 0.15-3.57，P = 0.03）。其他睡眠特征（DIS和DS）没有显着相关的认知decline.Conclusions：DMS和长睡眠时间与认知功能下降的正常和认知功能受损的老年人，分别。识别睡眠质量受损可能提供干预策略，以阻止认知功能正常的老年人的认知下降。
Study Objectives: To investigate the association between sleep-related characteristics and cognitive change over 3 years of follow up in an aged population.Methods: Sleep characteristics and covariates were assessed at baseline in a standardized interview and clinical examination of the population-based KORA Age Study (n = 740, mean age = 75 years). Cognitive score (determined by telephone interview for cognitive status, TICS-m) was recorded at baseline and 3 years later.Results: At baseline, 82.83% (n = 613) of participants had normal cognitive status, 13.51% (n = 100) were classified with mild cognitive impairment (MCI), and 3.64% (n = 27) with probable dementia. The effect of three distinct patterns of poor sleep (difficulties initiating [DIS] or maintaining sleep [DMS], daytime sleepiness [DS] or sleep duration) were considered on a change in cognitive score with adjustments for potential confounders in generalized linear regression models. Cognitive decline was more pronounced in individuals with DMS compared to those with no DMS (beta = 1.33, 95% CI = 0.41-2.24, P < 0.001). However, the predictive power of DMS was only significant in individuals with normal cognition and not impaired subjects at baseline. Prolonged sleep duration increased the risk for cognitive decline in cognitively impaired elderly (beta = 1.86, 95% CI = 0.15-3.57, P = 0.03). Other sleep characteristics (DIS and DS) were not significantly associated with cognitive decline.Conclusions: DMS and long sleep duration were associated with cognitive decline in normal and cognitively impaired elderly, respectively. The identification of impaired sleep quality may offer intervention strategies to deter cognitive decline in the elderly with normal cognitive function.