Characteristics of nociceptors in the periodontium - an in vitro study in rats
Characteristics of nociceptors in the periodontium - an in vitro study in rats
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DOI：
10.1016/j.brainresbull.2003.10.005
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发表时间：
2004-01-15
影响因子：
3.8
通讯作者：
Nasution, FH
中科院分区：
文献类型：
--
作者：
Toda, K;Zeredo, JL;Nasution, FH
近年来的研究表明，伤害感受器根据其生理特性可分为不同的类型。这些研究阐明了各种伤害感受器类型的频率分布在不同的身体部位和动物物种之间是不同的。在本研究中，我们研究了大鼠牙周损伤感受器在体外颌神经制剂中的生理特性。记录下肺泡下神经功能单丝的反应。为了确定伤害感受器的类型，使用校准的冯弗雷丝，热和缓激素（BK）刺激。我们在下门牙牙周韧带中发现了5种伤害感受器亚型：adelta -高阈值机械性伤害感受器（Adelta-HTM, n = 28）、adelta -机械性热伤害感受器（Adelta-MH, n = 6）、adelta -多模态伤害感受器（Adelta-POLY, n = 26）、c -高阈值机械性伤害感受器（C-HTM, n = 3）和c -多模态伤害感受器（C-POLY, n = 4）。大多数伤害感受器是受adelta神经支配的，而只有少数受c神经支配的伤害感受器。目前的研究结果表明，牙周伤害感受器主要传递快速疼痛，因此可能在咀嚼过程中快速检测损伤相关刺激中发挥作用。(C) 2003 Elsevier Inc.版权所有。
Recent studies have indicated that nociceptors can be classified into various types according to their physiological properties. These studies have clarified that the frequency distribution of various nociceptor types is different among body sites and animal species. In the present study, we investigated the physiological properties of rat's periodontal nociceptors in an in vitro jaw-nerve preparation. Responses were recorded from functional single filaments in the inferior alveolar nerve. To determine the nociceptor type, calibrated von Frey filaments, heat, and bradykinin (BK) stimuli were used. We found five subtypes of nociceptors in the periodontal ligaments of the lower incisor: Adelta-high threshold mechanonociceptors (Adelta-HTM, n = 28), Adelta-mechanoheat nociceptors (Adelta-MH, n = 6), Adelta-polymodal nociceptors (Adelta-POLY, n = 26) C-high threshold mechanonociceptors (C-HTM, n = 3) and C-polymodal nociceptors (C-POLY, n = 4). Most nociceptors were Adelta-innervated, while only a small number of C-innervated nociceptors were found. The present results suggest that periodontal nociceptors transmit mainly fast pain, and may thus play a role in rapid detection of injure-related stimuli during mastication. (C) 2003 Elsevier Inc. All rights reserved.