Clasmatodendrosis correlating with periventricular hyperintensity in mixed dementia
Clasmatodendrosis correlating with periventricular hyperintensity in mixed dementia
复制标题
杂性痴呆与室周高信号相关的纤毛虫病
DOI：
10.1002/ana.10310
复制
发表时间：
2002
影响因子：
11.2
通讯作者：
S. Black
中科院分区：
文献类型：
--
作者：
D. Sahlas;J. Bilbao;R. Swartz;S. Black
我们报告一位79岁女性，可能患有阿兹海默症，磁共振成像显示脑室周围融合性白色高信号，尸检分析意外显示无脑室周围脱髓鞘或脑动脉硬化。然而，脑室周围白色物质中的星形胶质细胞表现出树枝状突起，定义为星形胶质细胞的胞质肿胀和空泡化，其树突呈串珠状。这一发现代表了一个以前未被认识到的脑室周围白色物质高信号的相关性。《神经病学年鉴》2002年;52：378-381
We report a 79‐year‐old woman with possible Alzheimer's disease and confluent periventricular white matter hyperintensities on magnetic resonance imaging in whom postmortem analysis unexpectedly demonstrated no periventricular demyelination or cerebral arteriosclerosis. However, astrocytes in the periventricular white matter exhibited clasmatodendrosis, defined as cytoplasmic swelling and vacuolation of astroglia, with beading of their dendrites. This finding represents a previously unrecognized correlate of periventricular white matter hyperintensities. Ann Neurol 2002;52:378–381