Effect of training and detraining on in vivo insulin sensitivity.
Effect of training and detraining on in vivo insulin sensitivity.
复制标题
训练和停止训练对体内胰岛素敏感性的影响。
DOI：
10.1055/s-2007-1024772
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发表时间：
1990
影响因子：
2.5
通讯作者：
T. Ishiko
中科院分区：
文献类型：
--
作者：
J. Nagasawa;Y. Sato;T. Ishiko
在大鼠中测定胰岛素敏感性，以阐明在5周自愿训练后的第1天（训练状态）、第2天、第3天和第7天（各7只大鼠）以及第14天（n = 8）停止训练的效果。与未经训练的对照组相比，基础胰岛素和葡萄糖之间的关系朝着代谢胰岛素需求减少的方向转变（n = 20）。在胰岛素钳夹研究期间，为了维持所有组的血糖和胰岛素水平相当，与对照组（6.57 +/- 0.57）相比，葡萄糖输注速率必须显著增加（p <0.01）至9.92 +/- 1.12 mg.kg-1.min-1。这种敏感性的改善在训练后持续了2天，但在训练后7天组中显著降低（p <0.01）。综上所述，本研究表明，可以通过大鼠自愿训练来确定训练对胰岛素敏感性的影响。这种训练效果在训练后持续2天。
Insulin sensitivity was determined in rats to clarify the effect of detraining at 1 (trained state), 2, 3, and 7 days (7 rats each) and 14 days (n = 8) after five weeks of voluntary training using euglycemic insulin clamp technique. The relationship between basal insulin and glucose shifted towards a decrease in metabolic insulin needs compared to untrained controls (n = 20). During the insulin clamp study, to maintain comparable plasma glucose and insulin levels in all groups, the glucose infusion rate had to be increased significantly (p less than 0.01) to 9.92 +/- 1.12 mg.kg-1.min-1 compared to control group (6.57 +/- 0.57). This improved sensitivity persisted for 2 days after training but was significantly lowered in the 7-days-after group (p less than 0.01). In summary, this study shows that training effect on insulin sensitivity can be determined after voluntary training in rat. This training effect lasted 2 days after training.