Procedural memory in patients with mild Alzheimer's disease
Procedural memory in patients with mild Alzheimer's disease
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DOI：
10.1159/000106633
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发表时间：
1997-07-01
影响因子：
2.4
通讯作者：
Yamadori, A
中科院分区：
文献类型：
--
作者：
Hirono, N;Mori, E;Yamadori, A
将轻度阿尔茨海默病（AD）患者的运动、知觉和认知技能学习能力与性别、年龄和教育程度匹配的对照组进行比较。我们排除了那些无法按照预定标准完成每项技能学习任务的患者。在那些完成任务的人中，技能学习与正常对照组一样好。在认知和知觉技能学习方面，部分AD患者的认知记忆功能受损较严重，但陈述记忆功能受损较轻，不能完成任务，而所有患者均能完成运动任务。这些结果支持这样的观点，即轻度AD患者可以获得运动，知觉和认知技能，并且辅助程序技能的神经系统与陈述性记忆的神经系统无关。
Motor, perceptual, and cognitive skill learning abilities of mild Alzheimer's disease (AD) patients were compared to sex-, age-, and education-matched controls. We excluded patients who were unable to perform each skill learning task with a predetermined criterion. In those who completed the task, skill learning was as good as in normal controls. On the cognitive and perceptual skill learnings, some of the AD patients, whose cognitive but not declarative memory functions were more severely impaired than in those who completed the whole session, failed to complete the task, while all patients could complete the motor task. These results support the view that patients with mild AD can acquire motor, perceptual, and cognitive skills and that the neural system subserving procedural skill is not related to the neural systems for declarative memory.