CASE-CONTROL STUDY OF MASTOMYS-NATALENSIS AND HUMANS IN LASSA VIRUS-INFECTED HOUSEHOLDS IN SIERRA-LEONE
CASE-CONTROL STUDY OF MASTOMYS-NATALENSIS AND HUMANS IN LASSA VIRUS-INFECTED HOUSEHOLDS IN SIERRA-LEONE
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DOI：
10.4269/ajtmh.1983.32.829
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发表时间：
1983-01-01
影响因子：
3.3
通讯作者：
JOHNSON, KM
中科院分区：
文献类型：
--
作者：
KEENLYSIDE, RA;MCCORMICK, JB;JOHNSON, KM
在发生拉沙热病例的家庭中研究了拉沙病毒感染和抗体，并与最近的邻居房屋和位于整个村庄的病例房屋的房屋进行了比较。在这些房屋中捕获的所有啮齿动物中，79%是Mastomys，这是拉沙病毒的天然宿主。啮齿类动物感染不是随机分布的，而是局部的。在案例房屋中的Mastomys中，39%为病毒血症，而对照房屋中为3.7%。病例房屋中的人抗体流行率为30%，而非病例房屋中的人抗体流行率为20%（P < 0.05，卡方检验，df = 2）。无论是血清转换，也没有抗体流行率与家庭规模或每间房的人数。在一半的病例和对照房屋中诱捕啮齿动物导致Mastomys减少2.2- 3.3倍。与未被困房屋的人相比，这种减少未能显著降低被困房屋的人对拉沙病毒的血清转化率。为了更好地评价这一程序作为在流行村庄阻断拉沙病毒传播的一种手段，将需要更完整的诱捕。
Lassa virus infection and antibodies were studied in households where Lassa fever cases occurred, and compared to those in nearest neighbor houses and far houses located across the village from case houses. Of all rodents caught in the houses, 79% were Mastomys, the natural reservoir of Lassa virus. Rodent infection was not randomly distributed, but rather focal. Of the Mastomys in case houses, 39% were viremic, compared to 3.7% in control houses. Human antibody prevalence in case houses was 30%, compared to 20% in non-case houses (P < 0.05, chi-square test, df = 2). Neither seroconversions nor antibody prevalence rates were associated with household size or number of persons per room. Trapping of rodents in half of the case and control houses resulted in a Mastomys reduction ranging from 2.2- to 3.3-fold. This reduction failed to significantly reduce the seroconversion rate to Lassa virus in the people of trapped houses compared to those in untrapped ones. More complete trapping will be needed in order to better evaluate this procedure as a means of interruption of Lassa virus transmission in endemic villages.