SCF and APC: the Yin and Yang of cell cycle regulated proteolysis
SCF and APC: the Yin and Yang of cell cycle regulated proteolysis
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DOI：
10.1016/s0955-0674(98)80119-1
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发表时间：
1998-12-01
影响因子：
7.5
通讯作者：
Peters, JM
中科院分区：
文献类型：
--
作者：
Peters, JM
细胞周期的进展需要两个泛素化复合物的活性，Skp1 -cullin- f -box蛋白复合物（SCF）和后期促进复合物/环体（APC）。过去一年的观察揭示了SCF和APC之间意想不到的相似之处，并对其活动的监管进行了详细的了解。现在已知这两种复合物以不同的形式存在，针对不同的底物进行泛素依赖的蛋白质水解。
Progression through the cell cycle requires the activity of two ubiquitination complexes, the Skp1 -cullin-F-box-protein complex (SCF) and the anaphase-promoting complex/cyclosome (APC). Observations in the past year have revealed unexpected similarities between the SCF and the APC and have allowed detailed insight into the regulation of their activities. Both complexes are now known to exist in different forms that target: different substrates for ubiquitin-dependent proteolysis.