Editor's Highlight: Lower Fractional Anisotropy in the Globus Pallidus of Asymptomatic Welders, a Marker for Long-Term Welding Exposure.
Editor's Highlight: Lower Fractional Anisotropy in the Globus Pallidus of Asymptomatic Welders, a Marker for Long-Term Welding Exposure.
复制标题
编辑亮点：无症状焊工苍白球各向异性分数较低，这是长期焊接暴露的标志。
DOI：
10.1093/toxsci/kfw116
复制
发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Huang,Xuemei
中科院分区：
文献类型：
--
作者：
Lee,Eun-Young;Flynn,MichaelR;Du,Guangwei;Lewis,MechelleM;Herring,AmyH;VanBuren,Eric;VanBuren,Scott;Kong,Lan;Mailman,RichardB;Huang,Xuemei
简介：焊接烟雾含有几种金属，包括锰（Mn），铁（Fe）和铜（Cu），在高暴露下可能会共同影响焊接相关的神经毒性。这些金属在大脑中的积累与神经病理学之间的关系，特别是在亚临床暴露水平的焊工中，尚不清楚。本研究探讨了基底神经节（BG）区域的无症状焊工使用扩散张量成像（DTI）的微结构完整性：主题（n = 43）和没有（年龄和性别匹配的对照组; n = 31）焊接的历史进行了研究。职业问卷估计短期（HrsW;焊接小时数和E90;累积暴露，过去90天）和长期（YrsW;焊接和ELT总年数;累积暴露，寿命）暴露。获得全血金属水平（Mn、Fe和Cu）。测量脑MRI苍白球指数（PI）、R1（1/T1）和R2*（1/T2*），以估计BG [尾状核、壳核和苍白球（GP）]中Mn和Fe的蓄积。DTI被用来评估BG微结构的差异，并与曝光measurements.Results：当与对照组相比，焊工有显着降低分数各向异性（FA）在GP。在焊工中，GP FA值与YrsW、血Mn和PI呈非线性关系。GP FA下降后，达到临界水平的YrsW或Mn，而它随着PI值的增加而下降，直到在最高PI值的平台。GP FA，但是，没有显示出任何关系与短期暴露测量（HrsW，E90），血液铜和铁，orR 2 * values.Conclusion：GP FA捕获与慢性低水平锰暴露的微观结构变化，并可能作为一个生物标志物的神经毒性在无症状焊工。
Introduction: Welding fumes contain several metals including manganese (Mn), iron (Fe), and copper (Cu) that at high exposure may co-influence welding-related neurotoxicity. The relationship between brain accumulation of these metals and neuropathology, especially in welders with subclinical exposure levels, is unclear. This study examined the microstructural integrity of basal ganglia (BG) regions in asymptomatic welders using diffusion tensor imaging (DTI).Methods: Subjects with (n = 43) and without (age- and gender-matched controls; n = 31) history of welding were studied. Occupational questionnaires estimated short-term (HrsW; welding hours and E90; cumulative exposure, past 90 days) and long-term (YrsW; total years welding and ELT; cumulative exposure, lifetime) exposure. Whole blood metal levels (Mn, Fe, and Cu) were obtained. Brain MRI pallidal index (PI), R1 (1/T1), and R2* (1/T2*) were measured to estimate Mn and Fe accumulation in BG [caudate, putamen, and globus pallidus (GP)]. DTI was used to assess BG microstructural differences, and related with exposure measurements.Results: When compared with controls, welders had significantly lower fractional anisotropy (FA) in the GP. In welders, GP FA values showed non-linear relationships to YrsW, blood Mn, and PI. GP FA decreased after a critical level of YrsW or Mn was reached, whereas it decreased with increasing PI values until plateauing at the highest PI values. GP FA, however, did not show any relationship with short-term exposure measurements (HrsW, E90), blood Cu and Fe, orR2* values.Conclusion: GP FA captured microstructural changes associated with chronic low-level Mn exposure, and may serve as a biomarker for neurotoxicity in asymptomatic welders.