Early detection of sporadic pancreatic cancer: summative review.
Early detection of sporadic pancreatic cancer: summative review.
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DOI：
10.1097/mpa.0000000000000368
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发表时间：
2015-07
期刊：
影响因子：
2.9
通讯作者：
Wong D
中科院分区：
文献类型：
--
作者：
Chari ST;Kelly K;Hollingsworth MA;Thayer SP;Ahlquist DA;Andersen DK;Batra SK;Brentnall TA;Canto M;Cleeter DF;Firpo MA;Gambhir SS;Go VL;Hines OJ;Kenner BJ;Klimstra DS;Lerch MM;Levy MJ;Maitra A;Mulvihill SJ;Petersen GM;Rhim AD;Simeone DM;Srivastava S;Tanaka M;Vinik AI;Wong D
补充数字内容可在文本中找到。据估计，到2020年，胰腺癌（PC）将成为美国癌症死亡的第二大原因。早期发现是提高PC生存率的关键。为了满足这一迫切需求，肯纳家庭研究基金会于2014年与美国胰腺协会和日本胰腺协会45周年纪念会议一起举办了首届散发性胰腺癌早期检测峰会。这次来自科学，实践和临床研究的国际代表的开创性会议旨在促进具有挑战性的跨学科对话，以产生创新的想法，从而为该领域的未来创造一个明确的合作战略途径。深入总结了该领域目前的努力，分析了特定专业领域的差距，以及早期检测中存在的挑战，这些都是在不同的调查领域中提出的：早期检测案例：定义，检测，生存和挑战;早期检测的生物标志物;成像;和合作研究。此外，在家族性PC的努力的概述是本文的增编。从峰会的讨论中可以清楚地看出，只有研究者、机构和资助者之间的战略性合作才能使散发性PC的早期发现取得重大进展。
Supplemental digital content is available in the text. Pancreatic cancer (PC) is estimated to become the second leading cause of cancer death in the United States by 2020. Early detection is the key to improving survival in PC. Addressing this urgent need, the Kenner Family Research Fund conducted the inaugural Early Detection of Sporadic Pancreatic Cancer Summit Conference in 2014 in conjunction with the 45th Anniversary Meeting of the American Pancreatic Association and Japan Pancreas Society. This seminal convening of international representatives from science, practice, and clinical research was designed to facilitate challenging interdisciplinary conversations to generate innovative ideas leading to the creation of a defined collaborative strategic pathway for the future of the field. An in-depth summary of current efforts in the field, analysis of gaps in specific areas of expertise, and challenges that exist in early detection is presented within distinct areas of inquiry: Case for Early Detection: Definitions, Detection, Survival, and Challenges; Biomarkers for Early Detection; Imaging; and Collaborative Studies. In addition, an overview of efforts in familial PC is presented in an addendum to this article. It is clear from the summit deliberations that only strategically designed collaboration among investigators, institutions, and funders will lead to significant progress in early detection of sporadic PC.