Association of Aortic Stiffness With Cognition and Brain Aging in Young and Middle-Aged Adults: The Framingham Third Generation Cohort Study.
Association of Aortic Stiffness With Cognition and Brain Aging in Young and Middle-Aged Adults: The Framingham Third Generation Cohort Study.
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DOI：
10.1161/hypertensionaha.115.06610
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发表时间：
2016-03
期刊：
影响因子：
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通讯作者：
Seshadri S
中科院分区：
文献类型：
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作者：
Pase MP;Himali JJ;Mitchell GF;Beiser A;Maillard P;Tsao C;Larson MG;DeCarli C;Vasan RS;Seshadri S
主动脉僵硬与晚年认知能力下降和脑血管疾病相关，尽管这些相关性尚未在年轻人中进行研究。从病理生理学和公共卫生的角度来看，了解年轻时主动脉僵硬对大脑的影响非常重要。本研究的目的是检查主动脉僵硬度与认知功能和大脑老化的横截面相关性，在心脏研究第三代队列（47%男性，平均年龄= 46岁）。参与者完成了主动脉僵硬度（颈动脉-股动脉脉搏波速度）评估，神经心理学测试电池评估多个领域的认知表现和磁共振成像检查脑损伤的亚临床标志物。在调整后的回归模型中，主动脉僵硬度越高，处理速度和执行功能越差（路线制作B-A; β±标准误= −0.08±0.03，p < 0.01），侧脑室容积较大（β±标准误差= 0.09±0.03，p < 0.01）和更大的白色物质高信号负荷（β±标准误差= 0.09±0.03，p < 0.001）。当按年龄分层时，年轻人（30-45岁）的主动脉僵硬度与侧脑室容积相关，而中年人（45-65岁）的主动脉僵硬度与白色损伤和认知相关。总之，主动脉僵硬度与年轻至中年人的认知功能和亚临床脑损伤标志物相关。需要进行前瞻性研究，以检查青年期主动脉硬化是否与以后生活中的血管认知障碍有关。
Aortic stiffness is associated with cognitive decline and cerebrovascular disease late in life, although these associations have not been examined in young adults. Understanding the effects of aortic stiffness on the brain at a young age is important both from a pathophysiological and public health perspective. The aim of the present study was to examine the cross-sectional associations of aortic stiffness with cognitive function and brain aging in the Framingham Heart Study Third Generation cohort (47% men, mean age = 46 years). Participants completed assessment of aortic stiffness (carotid-femoral pulse wave velocity), a neuropsychological test battery assessing multiple domains of cognitive performance and magnetic resonance imaging to examine subclinical markers of brain injury. In adjusted regression models, higher aortic stiffness was associated with poorer processing speed and executive function (Trail Making B-A; β±standard error = −0.08±0.03, p < 0.01), larger lateral ventricular volumes (β± standard error = 0.09±0.03, p < 0.01) and a greater burden of white matter hyperintensities (β± standard error = 0.09±0.03, p < 0.001). When stratifying by age, aortic stiffness was associated with lateral ventricular volume in young adults (30-45 years), whereas aortic stiffness was associated with white matter injury and cognition in midlife (45-65 years). In conclusion, aortic stiffness was associated with cognitive function and markers of subclinical brain injury in young to middle-aged adults. Prospective studies are needed to examine whether aortic stiffening in young adulthood is associated with vascular cognitive impairment later in life.