The Effect of Lifestyle Intervention on Body Composition, Glycemic Control, and Cardiorespiratory Fitness in Polycystic Ovarian Syndrome: A Systematic Review and Meta-Analysis
The Effect of Lifestyle Intervention on Body Composition, Glycemic Control, and Cardiorespiratory Fitness in Polycystic Ovarian Syndrome: A Systematic Review and Meta-Analysis
复制标题
DOI：
10.1123/ijsnem.2013-0232
复制
发表时间：
2015-12-01
影响因子：
2.5
通讯作者：
Smart, Neil
中科院分区：
文献类型：
--
作者：
Haqq, Liza;McFarlane, James;Smart, Neil
简介：多囊卵巢综合征（PCOS）影响18-22%的育龄妇女。我们进行了一项系统回顾和荟萃分析，以量化生活方式（运动和饮食）干预对多囊卵巢综合征各种临床结果的预期益处。方法：通过系统检索PubMed、护理与相关健康文献累积索引（Cumulative Index to Nursing and Allied Health Literature）和Cochrane对照试验注册表（1966年至2013年4月），利用PCOS、运动、饮食和生活方式干预等关键概念，确定潜在的研究。结果:明显改善女性被认为接受生活方式干预和常规治疗,身体成分参数的身体质量指数,平均差(MD) = -0.12 kg.m(2)(95%可信区间[-0.22,0.03],p = .009),体重MD = -3.42公斤(95%可信区间[-4.86,-1.99],p < .00001),腰围MD = -1.64厘米(95%可信区间[-2.09,-1.19],p < .00001),腰臀比率MD = 0.03(95%可信区间[-0.05,0.01],p = .0002),医学博士和体脂% = -1.71%(95%可信区间[-3.10,-0.32],p = .02点)。胰岛素无改善，MD = -1.21 pmol/L （95% CI [-3.06, 0.63], p = .20）。血脂没有改善，总胆固醇MD = -0.02 mmol/L （95% CI [-0.25, 0.21], p = 0.89）。c反应蛋白显著降低，MD = -0.47 mmol/L （95% CI [-0.80, 0.15], p = 0.004）。单独运动降低静息心率（MD = -1.89次）也能显著改善心肺功能。分钟(1)(95% CI [-2.90, -0.88], p = .0002),和峰值最大,MD = 4.86 ml.kg(1)。min(-1) （95% CI [2.83, 6.88], p < 0.00001）。生活方式治疗也有改善，峰值VO2 MD = 5.09 ml.kg（-1）。min(-1) （95% CI [3.13, 7.05], p < 0.00001）。结论：我们的分析表明，生活方式干预是改善多囊卵巢综合征女性身体成分和心肺健康的最佳方法。
Introduction: Polycystic ovarian syndrome (PCOS) affects 18-22% women of reproductive age. We conducted a systematic review and meta-analysis to quantify expected benefits of lifestyle (exercise and dietary) interventions on various clinical outcomes in PCOS.Methods: Potential studies were identified by conducting systematic search of PubMed, the Cumulative Index to Nursing and Allied Health Literature, and Cochrane controlled trials registry (1966 to April 2013) using key concepts of PCOS, exercise, dietary and lifestyle interventions.Results: Significant improvements were seen in women who received lifestyle intervention vs. usual care, in body composition parameters of body mass index, mean difference (MD) = -0.12 kg.m(-2) (95% CI [-0.22, 0.03], p = .009), body mass MD = -3.42 kg (95% CI [-4.86, -1.99], p < .00001), waist circumference MD = -1.64 cm (95% CI [-2.09, -1.19],p < .00001), waist hip ratio MD = 0.03 (95% CI [-0.05, 0.01], p = .0002), and body fat % MD = -1.71% (95% CI [-3.10, -0.32], p = .02). Insulin did not improve, MD = -1.21 pmol/L (95% CI [-3.06, 0.63], p = .20). Lipid profile did not improve, total cholesterol MD = -0.02 mmol/L (95% CI [-0.25, 0.21], p = .89). C-reactive protein was significantly lower, MD = -0.47 mmol/L (95% CI [-0.80, 0.15], p = .004). Significant improvements were also observed in cardiorespiratory fitness with exercise alone reducing resting heart rate, MD = -1.89 beats.min(-1) (95% CI [-2.90, -0.88], p = .0002), and peak VO2, MD = 4.86 ml.kg(-1).min(-1) (95% CI [2.83, 6.88], p < .00001). Lifestyle therapy also improved, peak VO2 MD = 5.09 ml.kg(-1).min(-1) (95% CI [3.13, 7.05], p < .00001).Conclusions: Our analyses suggest lifestyle intervention is optimal for improving body composition and cardiorespiratory fitness in women with PCOS.