CEREBROVASCULAR AMYLOID IN SCRAPIE-AFFECTED SHEEP REACTS WITH ANTIBODIES TO PRION PROTEIN
CEREBROVASCULAR AMYLOID IN SCRAPIE-AFFECTED SHEEP REACTS WITH ANTIBODIES TO PRION PROTEIN
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DOI：
10.1016/0304-3940(88)90067-5
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发表时间：
1988-10-05
影响因子：
2.5
通讯作者：
GLENNER, GG
中科院分区：
文献类型：
--
作者：
ALLSOP, D;IKEDA, S;GLENNER, GG
在绵羊中自然发生的和实验性瘙痒症的免疫组织化学研究中，发现脑血管淀粉样蛋白的沉积物与仓鼠瘙痒症朊病毒蛋白（PrP 27-30）的抗体反应，但不与淀粉样蛋白β-受体的抗体反应。阿尔茨海默病的蛋白质。它的结论是，这种血管淀粉样蛋白是由PrP形成的，因此与瘙痒症感染密切相关。这种淀粉样蛋白很可能是由宿主前体蛋白形成的，是痒病病原体入侵的特定病理结果。
In an immunohistochemical study of naturally-occurring and experimental scrapie in sheep, deposits of cerebrovascular amyloid were found to react with antibodies to hamster scrapie prion protein (PrP 27-30), but not with antibodies to the amyloid .beta.-protein of Alzheimer''s disease. It is concluded that this vascular amyloid is formed from PrP and is therefore closely associated with scrapie infection. It is likely that this amyloid is formed from a host precursor protein as a specific pathological consequence of invasion by the scrapie agent.