EFFECTS OF GASTRIC PACING ON CANINE GASTRIC-MOTILITY AND EMPTYING
EFFECTS OF GASTRIC PACING ON CANINE GASTRIC-MOTILITY AND EMPTYING
复制标题
DOI：
10.1152/ajpgi.1993.265.4.g767
复制
发表时间：
1993-10-01
影响因子：
--
通讯作者：
KELLY, KA
中科院分区：
文献类型：
--
作者：
EAGON, JC;KELLY, KA
在狗和人身上已经实现了胃起搏，但它对胃动力和胃排空的影响还没有得到彻底的研究。7只狗将双极电极放置在幽门近端1和10 cm处，用于反向和正向起搏；单极记录电极和应变片放置在幽门近端3、5和7 cm处。复苏后，分别在不起搏、反向起搏和前向起搏(频率高于起搏电位频率0.5次/min)三种状态下，测量混合餐(50G1Tc99m标记肝脏和250mlIn-111标记的5%葡萄糖肉汤溶液)的肌电活动、收缩活动和胃排空。7只犬中有6只反向起搏使胃窦90%的起搏电位和蠕动波方向逆转，固体排空延迟期延长，固体和液体半排空时间延长，胃窦运动指数增加。前向起搏有起搏电位，但对排空或胃窦收缩没有一致的影响。总之，反向胃起搏通过逆转胃窦蠕动的方向和增加胃窦运动指数来减缓可消化固体和液体的胃排空，而向前起搏则没有这种作用。
Gastric pacing has been achieved in dogs and humans, but its effects on gastric motility and emptying have not been thoroughly explored. Seven dogs had bipolar electrodes placed 1 and 10 cm proximal to the pylorus for reverse and forward pacing and monopolar recording electrodes and strain gauges placed 3, 5, and 7 cm proximal to the pylorus. After recovery, myoelectrical and contractile activity and gastric emptying of a mixed meal (50 g1 Tc-99m-labeled liver and 250 ml In-111-labeled 5% dextrose broth solution) were measured in each of three conditions: no pacing, reverse pacing, and forward pacing (frequency 0.5 cycles/min above intrinsic pacesetter potential frequency). Reverse pacing reversed the direction of >90% of antral pacesetter potentials and peristaltic waves in six of seven dogs, prolonged the lag phase of solid emptying, prolonged the half emptying time of solids and liquids, and increased the antral motility index. Forward pacing entrained pacesetter potentials but had no consistent effect on emptying or antral contractions. In conclusion, reverse gastric pacing slows gastric emptying of digestible solids and liquids by reversing the direction of antral peristalsis and increasing the antral motility index, whereas forward pacing has no such effects.