Visual compatibility of 30 additives with a parenteral nutrient solution.
Visual compatibility of 30 additives with a parenteral nutrient solution.
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30 种添加剂与肠外营养液的视觉兼容性。
DOI：
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发表时间：
1979
期刊：
影响因子：
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通讯作者：
A. Welco
中科院分区：
文献类型：
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作者：
N. Athanikar;B. Boyer;R. Deamer;H. Harbison;R. S. Henry;R. Jurgens;C. Mett;R. Sturgeon;M. VanLeuven;A. Welco
研究了30种药物添加剂与全肠外营养液（4.25%氨基酸、25%葡萄糖注射液）的视觉相容性。每种药物添加剂混合三种TPN溶液；其中两种在4℃下储存22小时，然后将其平衡到室温两小时。从每个TPN溶液中取出两个25ml的样品，立即或在25小时后检查视觉外观，颗粒物水平和ph。使用显微镜计数和测量从0.8微米过滤器上过滤的样品中的颗粒。只有含有两性霉素B的TPN溶液显示任何视觉变色或沉淀。所有两性霉素B样品和25小时氨苄西林钠样品均超过USP颗粒物规格。其他TPN溶液的单个颗粒物水平各不相同，但符合USP规范。除盐酸四环素使TPN溶液的pH值降低0.9个单位外，其他添加剂对TPN溶液的pH值影响不大（pH值为6.45）。两性霉素B和氨苄西林钠被认为与TPN溶液视觉不相容。所有其他药物添加剂测试与TPN溶液视觉相容。
The visual compatibility of 30 drug additives with total parenteral nutrient (TPN) solutions (4.25% amino acids, 25% dextrose injection) was studied. For each drug additive, three TPN solutions were mixed; two were stored for 22 hours at 4 C then allowed to equilibrate to room temperature for two hours. Two 25-ml samples from each TPN solution were examined immediately or after 25 hours for visual appearance, particulate matter levels and pH. A microscope was used to count and measure particles filtered from samples on a 0.8-micrometer filter. Only the TPN solutions containing amphotericin B showed any visual discoloration or precipitation. All amphotericin B samples and the 25-hour ampicillin sodium samples exceeded USP particulate matter specifications. Individual particulate matter levels of the other TPN solutions varied but met USP specifications. With the exception of tetracycline hydrochloride, which dropped the TPN solution's pH 0.9 units, the additives had little effect on pH of the TPN solutions (pH 6.45). Amphotericin B and ampicillin sodium were considered visually incompatible with TPN solutions. All other drug additives tested were visually compatible with TPN solutions.