Data Commons to Support Pediatric Cancer Research.
Data Commons to Support Pediatric Cancer Research.
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DOI：
10.14694/edbk_175029
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发表时间：
2017-01-01
期刊：
影响因子：
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通讯作者：
Grossman, Robert
中科院分区：
文献类型：
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作者：
Volchenboum, Samuel L;Cox, Suzanne M;Grossman, Robert
高通量生物医学研究数据的成本下降和保真度的提高导致了癌症监测和治疗的复兴。然而，这些数据的数量、速度和复杂性已经超过了越来越多的研究人员收集和分析这些信息的能力。通过集中数据、处理能力和工具，有一个宝贵的机会来共享资源，从而提高研究的效率、力量和影响。在本文中，我们描述了当前的数据共享以及它们如何在肿瘤学领域中运作，包括国际神经母细胞瘤风险组数据共享作为范例案例的概述。我们概述了构建数据共享的实际步骤和注意事项。最后，我们讨论了在儿童癌症研究背景下创建数据共享的独特机会和好处，强调了临床肿瘤学的特殊优势，并提出了下一步的建议。
The falling costs and increasing fidelity of high-throughput biomedical research data have led to a renaissance in cancer surveillance and treatment. Yet, the amount, velocity, and complexity of these data have overcome the capacity of the increasing number of researchers collecting and analyzing this information. By centralizing the data, processing power, and tools, there is a valuable opportunity to share resources and thus increase the efficiency, power, and impact of research. Herein, we describe current data commons and how they operate in the oncology landscape, including an overview of the International Neuroblastoma Risk Group data commons as a paradigm case. We outline the practical steps and considerations in building data commons. Finally, we discuss the unique opportunities and benefits of creating a data commons within the context of pediatric cancer research, highlighting the particular advantages for clinical oncology and suggested next steps.