Serum Total p-Cresol and Indoxyl Sulfate Correlated With Stage of Chronic Kidney Disease in Renal Transplant Recipients
Serum Total p-Cresol and Indoxyl Sulfate Correlated With Stage of Chronic Kidney Disease in Renal Transplant Recipients
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DOI：
10.1016/j.transproceed.2011.11.023
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发表时间：
2012-04-01
影响因子：
0.9
通讯作者：
Chen, C. -H.
中科院分区：
文献类型：
--
作者：
Huang, S. -T.;Shu, K. -H.;Chen, C. -H.
背景。尿毒症毒素被认为是慢性肾病（CKD）患者心血管和死亡的危险因素。对甲酚和硫酸吲哚酚均已被证明可在体外诱导尿毒症患者的氧化应激和随后的内皮功能障碍。我们的研究评估了对甲酚和硫酸吲哚酚的水平，以及它们是否有助于移植受者 CKD 的进展。方法。我们回顾性评估了1987年2月至2010年6月在我中心接受移植的95例患者；受者的平均移植持续时间为 5.3 +/- 4.9 年，平均年龄为 47.8 +/- 14.1 岁。其中，56.8%（54/95）为男性。选择肾小球滤过率(GFR)≥60 mL/min/1.73 m(2)的患者为第1组(n = 35)，选择GFR < 60 mL/min/1.73 m(2)的患者为第2组(n = 60)。比较各组之间的人口统计学和临床数据。还获得了对甲酚和硫酸吲哚酚的血清和尿液水平。结果。晚期 CKD 阶段的基线血清对甲酚和硫酸吲哚酚水平显着升高（P = .001 和
Background. Uremic toxins are considered cardiovascular and mortality risk factors in chronic kidney disease (CKD) patients. Both p-cresol and indoxyl sulfate have been shown to induce oxidative stress in vitro and subsequent endothelial dysfunction in uremic patients. Our study evaluated the levels of p-cresol and indoxyl sulfate, and whether they contribute to the progression of CKD in transplant recipients.Methods. We retrospectively evaluated 95 patients who had received a transplant from February 1987 to June 2010 in our center; the recipients had a mean transplant duration of 5.3 +/- 4.9 years and a mean age of 47.8 +/- 14.1 years. Among them, 56.8% (54/95) were male. Patients with glomerular filtration rate (GFR) >= 60 mL/min/1.73 m(2) were selected for group 1 (n = 35), and those with GFR < 60 mL/min/1.73 m(2) were selected for group 2 (n = 60). Demographic and clinical data were compared between groups. Serum and urine levels of p-cresol and indoxyl sulfate were also obtained.Results. Baseline serum p-cresol and indoxyl sulfate levels were significantly higher in advanced CKD stages (P = .001 and